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Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 79, Number 4, p.1073-1079 (2010)

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Keywords : 5-fluorouracil (5-FU), Anticancer drug, calcium chloride, Cancer drug, Carboxymethyl chitin, Carrier systems, chitin, Controlled drug delivery, Drug release study, Emulsification, encapsulation, Encapsulation efficiency, Ferromagnetic materials, Ferromagnetic properties, Ferromagnetism, Fourier transform infrared spectroscopy, FTIR, In-vitro, Magnetic properties, Mouse cells, MTT assays, Nanoparticles, SEM, sustained drug release

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2010

Abstract : Carboxymethyl chitin (CMC) nanoparticles were prepared by cross-linking of CMC solution with CaCl2 and FeCl3. The cytotoxicity of the CMC nanoparticles was evaluated using MTT assay and they were found to be non-toxic into L929 mouse cells. The antibacterial and magnetic properties of the CMC nanoparticles were also studied. The prepared CMC nanoparticles were characterized using SEM and FTIR. The model hydrophobic anticancer drug 5-fluorouracil (5-Fu) was loaded into CMC nanoparticles via emulsion cross-linking method. The encapsulation efficiency and in-vitro drug release behaviour of drug-loaded nanoparticles were studied by UV spectrophotometer. Drug release studies showed that the CMC nanoparticles showed controlled and sustained drug release at pH 6.8. Moreover, the prepared nanoparticles were also found to be antibacterial and their magnetic properties reveals for their potential use in drug tracking. These results indicated that CMC nanoparticles are a promising carrier system for controlled drug delivery.

Cite this Research Publication : A. Dev, Mohan, J. C., Sreeja, V., Tamura, H., Patzke, G. R., Hussain, F., Weyeneth, S., Nair, S. V., and Dr. Jayakumar Rangasamy, “Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications”, Carbohydrate Polymers, vol. 79, pp. 1073-1079, 2010.

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