Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems. © 2015 The International CCN Society
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Y. S.D., S., J., J.K., T., S., G., A.A., K., A., S., T.S., K. Prasad, A., P., B.L., S., and f, G. Ha b, “A pathway map of glutamate metabolism”, Journal of Cell Communication and Signaling, pp. 1-7, 2015.