ProgramsView all programs
From the news
- Chancellor Amma Addresses the Parliament of World’s Religions
- Amrita Students Qualify for the European Mars Rover Challenge
Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : J Dermatol Sci
Source : J Dermatol Sci, Volume 89, Issue 2, p.146-154 (2018)
Keywords : Administration, Cutaneous, Animals, epidermis, Gold, Hindlimb, male, Metal Nanoparticles, Models, Animal, particle size, permeability, Rats, Rats, Sprague-Dawley, Skin Absorption
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2018
Abstract : BACKGROUND: Transdermal particulate penetration across thick-skin, such as that of palms and sole, is particularly important for drug delivery for disorders such as small fiber neuropathies. Nanoparticle-based drug delivery across skin is believed to have much translational applications, but their penetration especially through thick-skin, is not clear.OBJECTIVE: This study specifically investigates the effectiveness of gold nanoparticles (AuNPs) for thick-skin penetration, especially across the stratum corneum (SC) as a function of particle size./ppbMETHODS: /bThe thick-skinned hind-paw of rat was used to characterize depth and distribution of AuNPs of varying sizes, namely, 22±3, 105±11, and 186±20nm. Epidermal penetration of AuNPs was characterized both, in harvested skin from the hind-paw using a diffusion chamber, as well as in vivo./ppbRESULTS: /bHarvested skin segments exposed to 22nm AuNPs for only 3h demonstrated higher penetration (p0.05) as compared to the 105 and 186nm particles. In animal studies, hind-paw skin of adult rats exposed to AuNPs solution for the same time, demonstrated nanoparticles in blood on the 4th day, and histological analysis revealed AuNPs in epidermal layers just below the SC, with no apparent tissue response.CONCLUSION: We conclude that the thick-skin allows nanoparticle penetration and acts as a depot for release of AuNPs into circulation long after the initial exposure has ceased.
Cite this Research Publication : G. Raju, Katiyar, N., Vadukumpully, S., and Dr. Sahadev Shankarappa, “Penetration of Gold Nanoparticles across the Stratum Corneum Layer of Thick-Skin”, J Dermatol Sci, vol. 89, no. 2, pp. 146-154, 2018.