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Plumbagin Nanoparticles Induce Dose and pH Dependent Toxicity on Prostate Cancer Cells

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Current Drug Delivery

Source : Current Drug Delivery (2015)

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences

Year : 2015

Abstract : Stable nano-formulation of Plumbagin nanoparticles from Plumbago zeylanica root extract was explored as a potential natural drug against prostate cancer. Size and morphology analysis by DLS, SEM and AFM revealed the average size of nanoparticles prepared was 100±50nm. In vitro cytotoxicity showed concentration and time dependent toxicity on prostate cancer cells. However, plumbagin crude extract found to be highly toxic to normal cells when compared to plumbagin nanoformulation, thus confirming nano plumbagin cytocompatibility with normal cells and dose dependent toxicity to prostate cells. In vitro hemolysis assay confirmed the blood biocompatibility of the plumbagin nanoparticles. In wound healing assay, plumbagin nanoparticles provided clues that it might play an important role in the anti-migration of prostate cancer cells. DNA fragmentation revealed that partial apoptosis induction by plumbagin nanoparticles could be expected as a potent anti-cancer effect towards prostate cancer.

Cite this Research Publication : N. H.A., K.S., S., R.C., K., Shantikumar V Nair, and K., L. V., “Plumbagin Nanoparticles Induce Dose and pH Dependent Toxicity on Prostate Cancer Cells”, Current Drug Delivery, 2015.

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