Publisher : International Journal of Pharmaceutical Sciences Review and Research
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutics, Pharmacology
Year : 2013
Abstract : Eye is a sensitive organ and is easily injured and infected. Delivery of drugs into eye is complicated due to removal mechanism of precorneal area results decrease in therapeutic response. Conventional ocular delivery systems like solution, suspension, ointment shows some disadvantages such as rapid corneal elimination, repeated instillation of drug and short duration of action. In situ polymeric delivery system will help to achieve optimal concentration of drug at the target site, thereby helps to attain the desired therapeutic concentration. In situ gelling systems are liquid upon instillation and undergo a phase transition to form gel due to temperature modulation, change in pH and presence of ions. This review stresses the role of stimuli-responsive polymers in ocular in situ gelling system for prolonged contact time of drug with cornea, delay elimination and enhance bioavailability.