Publications

Abstract : Macrophage activation syndrome is a diagnosis along the spectrum of hemophagocytic lymphohistiocytosis (HLH) spectrum disorders. It is a rare, yet potentially fatal disease characterized by hyperferritinemia, coagulopathy and multisystem inflammation. Predictive biomarkers for outcomes in MAS are lacking and hence this study yearns to elucidate them. Activation of complement cascade and bacterial infection, causes a rise in the CRP whereas macrophage activation is represented by ferritin levels. These represent different immunological processes and are independent predictors of mortality in systemic inflammatory response.