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Pregnancy After Liver Transplantation: Outcomes From a Single-Center Experience

Publication Type : Journal Article

Publisher : Journal of Clinical and Experimental Hepatology

Source : Journal of Clinical and Experimental Hepatology, vol. 10, no. 4, pp. 329 - 333, 2020

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Keywords : fetal, maternal, tacrolimus

Campus : Kochi

School : School of Pharmacy

Department : Pharmacology

Year : 2020

Abstract : Background/Objectives Although much has been learnt regarding pregnancy after liver transplantation, data from India are scant. Hence, we evaluated the maternal and fetal outcomes of pregnancies after liver transplantation at our center. Methods We conducted a retrospective review of all patients who underwent liver transplantation and later conceived at our center between 2006 and 2019. Results Of the 750 liver transplantations performed at our center, 129 were female and 62 of them were in the childbearing age group (15–44 years). A total of seven conceptions occurred in seven patients during the study period. All the pregnancies occurred spontaneously. The median age of the patients at the time of liver transplantation and conception was 25 years (range, 24–33 years) and 29 years (range, 26–36 years), respectively. The median interval between transplantation and conception was 40 months (range, 7–48 months). All patients were on tacrolimus monotherapy. None of the patients had rejection during pregnancy despite a low median tacrolimus trough level of 2.7 ng/mL. Live birth (five cesarean and one normal) occurred in six of seven pregnancies at a median gestation age of 37.5 weeks. Mean birth weight was 3055.8 g (range, 2470–3635 g). Antenatal rubella infection and grade III intrauterine growth restriction resulting in still birth at 29 weeks occurred in one patient. The median postnatal follow-up was 25 months (range, 2–81 months). All babies and mothers were healthy. Conclusions Pregnancy after liver transplantation has a favorable outcome with a multidisciplinary team approach. There is a physiological reduction of tacrolimus trough levels during pregnancy for which dose augmentation is not usually required.

Cite this Research Publication : S. Sivaprasadan, Mathew, J. S., Surendran, S., and Dr. Umadevi P., “Pregnancy After Liver Transplantation: Outcomes From a Single-Center Experience”, Journal of Clinical and Experimental Hepatology, vol. 10, no. 4, pp. 329 - 333, 2020

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