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Preparation and characterization of novel β-chitin/nanosilver composite scaffolds for wound dressing applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 80, Number 3, p.761-767 (2010)

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Keywords : Anti-bacterial activity, Blood, Cell attachments, chitin, Chitin hydrogel, Composite scaffolds, Escherichia coli, Hydrogels, Nano silver, Scaffolds, scanning electron microscopy, SEM, Silver, silver nanoparticles, Staphylococcus aureus, Thermogravimetric analysis, wound dressing, Wound dressings, Wound healing applications, X ray diffraction, XRD

Campus : Kochi

School : Center for Nanosciences

Center : Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2010

Abstract : We developed novel β-chitin/nanosilver composite scaffolds for wound healing applications using β-chitin hydrogel with silver nanoparticles. The prepared nanosilver particles and nanocomposite scaffolds were characterized using SEM, FT-IR, XRD and TGA studies. The antibacterial, blood-clotting, swelling, cell attachment and cytotoxicity studies of the prepared composite scaffolds were evaluated. The prepared β-chitin/nanosilver composite scaffolds were bactericidal against Escherichia coli and Staphylococcus aureus and it showed good blood-clotting ability as well. Cell attachment studies using vero (epithelial) cells showed that the cells were well attached on the scaffolds. These results suggested that β-chitin/nanosilver composite scaffold could be a promising candidate for wound dressing applications.

Cite this Research Publication : P. T. S. Kumar, Abhilash, S., Manzoor, K., Nair, S. V., Tamura, H., and Dr. Jayakumar Rangasamy, “Preparation and characterization of novel β-chitin/nanosilver composite scaffolds for wound dressing applications”, Carbohydrate Polymers, vol. 80, pp. 761-767, 2010.

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