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Role of ethanol on aluminum induced biochemical changes on rat brain

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Indian Journal of Clinical Biochemistry

Source : Indian Journal of Clinical Biochemistry, Volume 21, Number 2, p.53-57 (2006)

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Keywords : acid phosphatase, alcohol, alkaline phosphatase, Aluminum, animal experiment, article, aspartate aminotransferase, Brain, brain protein, controlled study, enzyme activity, male, neurotoxicity, neurotoxin, nonhuman, protein analysis, rat

Campus : Kochi

School : School of Medicine

Department : Biochemistry

Year : 2006

Abstract : Aluminum and alcohol, both are well-accepted neurotoxin. The plausible mechanisms for their neurotoxicity are also common. Therefore, the effect of ethanol on aluminum induced biochemical changes in rat brain is being studied. In the present study, ethanol exposure significantly affected the aluminum and protein content of brain. The activities of acid phosphatase and alkaline phosphatase were also changed. Aluminum exposure, on the other hand, contributed significantly in the alterations of aluminum content, acid phosphatase activity and aspartate aminotransferase activity. Though ethanol co-exposure significantly influenced the aluminum load of brain, the interactions of these two neurotoxins were found to be significant only in case of acid phosphatase activity of brain. Therefore, it can be suggested that general neurotoxicity produced by aluminum is not modified by ethanol. However, the aluminum load caused by aluminum exposure, may be influenced by ethanol co-exposure.

Cite this Research Publication : S. K. Das, Vasudevan, D. M., and Nayak, P., “Role of ethanol on aluminum induced biochemical changes on rat brain”, Indian Journal of Clinical Biochemistry, vol. 21, pp. 53-57, 2006.

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