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SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns

Publication Type : Journal Article

Publisher : Physiol Genomics. 2021 Oct 1;53(10):433-440

Source : Physiol Genomics. 2021 Oct 1;53(10):433-440

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Keywords : SARS-CoV-2, Functional Genomics, Host Pathogenesis, lncRNAs Transgression

Campus : Amritapuri

School : School of Biotechnology

Department : biotechnology

Year : 2021

Abstract : SARS-CoV-2 harbors a lot of known unknown regions in the form of hypothetical open reading frames (ORFs). While the mechanisms underlying the disease pathogenesis is not clearly understood,there are molecules such as long noncoding RNAs (lncRNAs) that play a key regulatory role in the viral pathogenesis from endocytosis. We asked whether or not the lncRNAs in the host are associated with the viral proteins and argue that lncRNA-mRNAs molecules associated with viral infection may regulate SARS-CoV-2 pathogenesis. Towards the end of the perspective, we provide challenges and insights into the investigation of these transgression pathways.

Cite this Research Publication : Shukla N, Prasad A, Kanga U, Suravajhala R, Nigam VK, Kishor PBK, Polavarapu R, Chaubey G, Singh KK, Suravajhala P. SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns. Physiol Genomics. 2021 Oct 1;53(10):433-440. doi: 10.1152/physiolgenomics.00075.2021. Epub 2021 Sep 7. PMID: 34492207; PMCID: PMC8562947

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