Back close

Seabuckthron (Hippophae rhamnoides L.) Leaf Extract Ameliorates the Gamma Radiation Mediated DNA Damage and Hepatic Alterations

Publication Type : Journal Article

Thematic Areas : Biotech

Publisher : Indian Journal of Experimental Biology

Source : Indian Journal of Experimental Biology, vol. 52, p. 952, 2014.

Url :

Campus : Amritapuri, Coimbatore

School : School of Biotechnology, School of Engineering

Center : Biotechnology, Phytochemistry Labs

Department : biotechnology

Year : 2014

Abstract : In vitro assessment showed that H. rhamnoides (HrLE) extract possessed free radical scavenging activities and can protect gamma (γ) radiation induced supercoiled DNA damage. For in vivo study, Swiss albino mice were administered with HrLE (30 mg/kg body weight) for 15 consecutive days before exposing them to a single dose of 5 Gy of γ radiation. HrLE significantly prevented the radiation induced genomic DNA damage indicated as a significant reduction in the comet parameters. The lipid peroxidation, liver function enzymes, expression of phosphorylated NFκB (p65) and IκBα increased whereas the endogenous antioxidants diminished upon radiation exposure compared to control. Pretreatment of HrLE extract ameliorated these changes. Based on the present results it can be concluded that H. rhamnoides possess a potential preventive element in planned and accidental nuclear exposures.

Cite this Research Publication : A. Khan, Manna, K., Das, D. Kr, Sinha, M., Kesh, S. Bandhu, Das, U., Dey, R. Sharma, Dr. Asoke Banerji, Dey, S., and , “Seabuckthron (Hippophae rhamnoides L.) leaf extract ameliorates the gamma radiation mediated DNA damage and hepatic alterations.”, Indian Journal of Experimental Biology, vol. 52, p. 952, 2014.

Admissions Apply Now