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Single Step Electrospinning of Chitosan/poly(caprolactone) Nanofibers using Formic Acid/Acetone Solvent Mixture

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 80, Number 2, p.414-420 (2010

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Keywords : acetone, AFM, Beaded fibers, Biomedical applications, Caprolactone, chitin, chitosan, Concentration (process), Conductivity measurements, Electrospinning, Electrospuns, Fibrous scaffolds, Fourier transform infrared spectroscopy, FTIR, matrix, Nanofibers, Nanofibrous scaffolds, Novel solvents, Optimum value, Organic acids, Scaffolds, SEM, Single-step, Solvent mixtures, Spinnability, Thermal properties, Thermodynamic properties

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2010

Abstract : A fibrous scaffold comprising of chitosan (CS) and poly(ε-caprolactone) (PCL) was electrospun from a novel solvent mixture consisting of formic acid and acetone. CS concentration was varied from 0.5% to 2% by fixing PCL concentration as a constant (6%). Selected CS concentration (1%) was further blended with 4-10% PCL to obtain fine nanofibers. The composition of mixing was selected as 25:75 (1:3), 50:50 (1:1) and 75:25 (3:1) of CS and PCL. Lower concentrations of PCL resulted in beaded fibers where as 8% and 10% of PCL in lower compositions of chitosan resulted in fine nanofibers. Viscosity and conductivity measurements revealed the optimum values for the spinnability of the polymer solutions. Optimized combination of CS and PCL (1% CS and 8% PCL) in 1:3 compositions was further characterized using SEM, FTIR, AFM and TG-DTA. The developed electrospun CS/PCL scaffold would be an excellent matrix for biomedical applications.

Cite this Research Publication : K. T. Shalumon, Anulekha, K. H., Girish C. M., Prasanth, R., Shantikumar V. Nair, and Dr. Jayakumar Rangasamy, “Single Step Electrospinning of Chitosan/poly(caprolactone) Nanofibers using Formic Acid/Acetone Solvent Mixture”, Carbohydrate Polymers, vol. 80, pp. 414-420, 2010.

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