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Small conjugate-based theranostic agents: an encouraging approach for cancer therapy

Publication Type : Journal Article

Thematic Areas : Advanced Materials and Green Technologies

Publisher : Chemical Society Reviews

Source : Chemical Society Reviews, Royal Society of Chemistry, Volume 44, Number 19, p.6670–6683 (2015)

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Campus : Coimbatore

School : School of Engineering

Center : Center for Excellence in Advanced Materials and Green Technologies

Department : Civil

Year : 2015

Abstract : The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment. Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy in medicine which exhibits improved biodistribution, selective cancer targeting ability, reduced toxicity, masked drug efficacy, and minimum side effects. The role of diagnosis tools in theranostics is to collect the information of the diseased state before and after specific treatment. Magnetic particle-, mesoporous silica-, various carbon allotrope-, and polymer nanoparticle-based theranostic systems are well accepted and clinically significant. Currently, small conjugate-based systems have received much attention for cancer treatment and diagnosis. The structural architecture of these systems is relatively simple, compact, biocompatible, and unidirectional. In this tutorial review, we summarize the latest developments on small conjugate based theranostic agents for tumor treatment and diagnosis using fluorescence and magnetic resonance imaging (MRI). © The Royal Society of Chemistry 2015.

Cite this Research Publication : R. Kumar, Shin, W. Sup, Sunwoo, K., Kim, W. Young, Koo, S., Bhuniya, S., and Kim, J. Seung, “Small conjugate-based theranostic agents: an encouraging approach for cancer therapy”, Chemical Society Reviews, vol. 44, pp. 6670–6683, 2015.

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