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Stereoselective synthesis of (S)-dapoxetine: a chiral auxiliary mediated approach

Publication Type : Journal Article

Publisher : Elsevier

Source : Tetrahedron Letters, 2013

Url :

Campus : Amritapuri

School : School of Biotechnology

Verified : No

Year : 2013

Abstract : An imidazolidin-2-one chiral auxiliary mediated acetate aldol reaction was explored in the enantioselective synthesis of (S)-dapoxetine (SSRI). The diastereoselective aldol adduct was transformed to highly enantiopure (S)-dapoxetine with overall good yield.

Cite this Research Publication : Gopal L. Khatik, Ratnesh Sharma, Varun Kumar, Mangilal Chouhan and Vipin A. Nair, "Stereoselective synthesis of (S)-dapoxetine: a chiral auxiliary mediated approach", Tetrahedron Letters 2013, 54, 5991-5993

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