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Synthesis and Antioxygenic Activities of Seabuckthorn Flavone-3-ols and Analogs

Publication Type : Journal Article

Thematic Areas : Biotech

Publisher : Bioorganic Medicinal Chemistry Letters

Source : Bioorganic & Medicinal Chemistry Letters, Volume 21, Number 18, p.5328 - 5330 (2011)

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Keywords : Radioprotectant

Campus : Amritapuri

School : School of Biotechnology

Center : Biotechnology, Phytochemistry Labs

Department : biotechnology

Year : 2011

Abstract : A practical synthesis of polyhydroxy- and regiospecifically methylated flavone-3-ols which are components of commercial ‘seabuckthorn flavone’ has been achieved by modified Algar–Flynn–Oyamada method. Antioxidant activities of seabuckthorn extracts, isolated products and a number of flavone-3-ols have been determined. Structure–activity relationships have been discussed. Amongst the compounds tested, gallic acid, which is also present in seabuckthorn, was found to be the most effective antioxidant and radioprotectant.

Cite this Research Publication : Pandurangan Nanjan, Chinchu Bose, and A. Banerji, “Synthesis and Antioxygenic Activities of Seabuckthorn Flavone-3-ols and Analogs”, Bioorganic & Medicinal Chemistry Letters, vol. 21, pp. 5328 - 5330, 2011.

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