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Synthesis and biological evaluation of chitin hydrogel/nano ZnO composite bandage as antibacterial wound dressing

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Journal of Biomedical Nanotechnology

Source : Journal of Biomedical Nanotechnology, Volume 8, Number 6, p.891-900 (2012)

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Keywords : Anti-Infective Agents, Antibacterial, antibacterial activity, antiinfective agent, article, bandage, Bandages, Biocompatible Materials, Blood, blood clotting, Blood Coagulation, Blood Platelets, calcium alginate, cell adhesion, Cell infiltration, Cell Survival, Cells, chitin, Chitin hydrogel, clinical evaluation, controlled study, Cytocompatible, Cytology, drug synthesis, Electron, Escherichia coli, fibroblast, Fibroblasts, Fourier Transform Infrared, freeze drying, human, human cell, Humans, Hydrocolloid, hydrogel, Hydrogels, Hydrogen-Ion Concentration, infrared spectroscopy, Materials Testing, Microbial Sensitivity Tests, microscopy, Nano-ZnO, nanocomposite, Nanocomposites, nonhuman, Scanning, scanning electron microscope, scanning electron microscopy, skin cell, Spectroscopy, Staphylococcus aureus, swelling, syringe, wound dressing, Wound dressings, X-Ray Diffraction, Zinc oxide

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2012

Abstract : We developed chitin hydrogel/nano ZnO composite bandages using chitin hydrogel and ZnO nanoparticles (nZnO). The homogenized mixture of chitin hydrogel and nZnO was freeze-dried to obtain micro-porous composite bandages. The prepared nanocomposite bandages were characterized using FT-IR, XRD and SEM. In addition, blood clotting, antibacterial, swelling, cytocompatibility and cell attachment capability of the prepared nanocomposite bandages were evaluated. The nanocomposite bandages showed enhanced swelling, blood clotting and antibacterial activity. The incorporation of nZnO helped to attain antibacterial activity. Cytocompatibility studies were carried out using human dermal fibroblast (HDF) cells proved the non-toxic nature of the composite bandages. HDF cell attachment and infiltration analysis showed that the cells were attached and penetrated into the interior (250μm) of the nanocomposite bandages. These studies revealed that, this nanocomposite can be used for burn, diabetic and chronic wound defects. Copyright © 2012 American Scientific Publishers All rights reserved.

Cite this Research Publication : P. T. S. Kumar, Lakshmanan, V. - K., Dr. Raja Biswas, Nair, S. V., and Dr. Jayakumar Rangasamy, “Synthesis and biological evaluation of chitin hydrogel/nano ZnO composite bandage as antibacterial wound dressing”, Journal of Biomedical Nanotechnology, vol. 8, pp. 891-900, 2012.

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