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Synthesis, characterization and antimicrobial activities of copper, nickel, cobalt, chromium complexes derived from (Z)-4-Fluoro-N-(2, 7-dimethylhept-6-enylidene) benzenamine

Publication Type : Journal Article

Publisher : Journal of the Brazilian Chemical Society

Source : Journal of the Brazilian Chemical Society, 28(5), 756-767.

Url :

Campus : Bengaluru

School : School of Engineering

Center : Amrita Innovation & Research

Department : Chemistry

Verified : Yes

Year : 2017

Abstract : Melonal is a relatively unexplored ingredient in the field of chemistry with excellent sensory properties. The synthesis and characterization of novel transition 3d metal complexes of copper(II), nickel(II), cobalt(II) and chromium(III) involving the Schiff base of melonal were explored to examine their biological activity. Characterization of the complexes was carried out using matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF), gas chromatography-massspectrometry (GC-MS), thermogravimetric analysis (TGA), UV-Visible and infrared (IR) spectrophotometry. The antimicrobial studies were conducted against six bacterial strains and six fungi. The minimum inhibition concentration observed was compared against the standard antibiotic gentamycin and the anti-fungal drug amphotericin. The activity studies indicated that cobalt(II) complex exhibited activity better than standard drug amphotericin against Penicillium chrysogenum. Molecular docking study confirms the protein binding and supports the experimental finding. Binuclear cobalt(II) and chromium(III) bridging complexes of Schiff base ligand were obtained. Keywords: azomethine, chromium(III) complex, melonal, bridging complex, docking, DFT

Cite this Research Publication : Rao, Sridhar & BILAL, I.MOHAMMED & Deivanayagam, Easwaramoorthi & kutti rani, Srinivasalu & Belliraj, Siva Kumar & Manohar, Sai. (2016). Synthesis, Characterization and Antimicrobial Activities of Copper, Nickel, Cobalt, Chromium Complexes Derived from (Z)-4-Fluoro-N-(2,7-dimethylhept-6-enylidene) benzenamine. Journal of the Brazilian Chemical Society. 28. 10.21577/0103-5053.20160224.

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