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Synthesis, Characterization, Cytotoxicity and Antibacterial Studies of Chitosan, O-carboxymethyl and N,O-carboxymethyl Chitosan Nanoparticles

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Carbohydrate Polymers

Source : Carbohydrate Polymers, Volume 78, Number 4, p.672 - 677 (2009)

Url : http://www.sciencedirect.com/science/article/pii/S0144861709003129(link is external)

Keywords : Antibacterial, Biomaterials, Carboxymethyl derivatives, Chitosan nanoparticles, cytotoxicity

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2009

Abstract : Chitosan (CS) is a naturally occurring biopolymer. It has important biological properties such as biocompatibility, antifungal and antibacterial activity, wound healing ability, anticancerous property, anticholesteremic properties, and immunoenhancing effect. Recently, CS nanoparticles have been used for biomedical applications. However, due to the limited solubility of CS in water its water-soluble derivatives are preferred for the above said applications. In this work, the nanoparticles of CS and its water-soluble derivatives such as O-carboxymethyl chitosan (O-CMC) and N,O-carboxymethyl chitosan (N,O-CMC) was synthesized and characterized. In addition, cytotoxicity and antibacterial activity of the prepared nanoparticles was also evaluated for biomedical applications.

Cite this Research Publication : A. Anitha, Rani, V. V. Divya, Krishna, R., Sreeja, V., Selvamurugan, N., Shantikumar V Nair, Tamura, H., and Dr. Jayakumar Rangasamy, “Synthesis, Characterization, Cytotoxicity and Antibacterial Studies of Chitosan, O-carboxymethyl and N,O-carboxymethyl Chitosan Nanoparticles”, Carbohydrate Polymers, vol. 78, pp. 672 - 677, 2009.

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