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Synthesis of tritium labelled precocenes

Publication Type : Journal Article

Thematic Areas : Biotech

Publisher : Journal of Labelled Compounds and Radiopharmaceuticals

Source : Journal of Labelled Compounds and Radiopharmaceuticals, Wiley Online Library, Volume 18, Number 12, p.1737–1741 (1981)

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Keywords : 2- dimethyl-4-chromanone-T, 2-dimethyl-1-4-chromanone-T, 6, 7-dimethoxy-2, 7-methoxy-2, antijuvenile hormones, precocene I-T, precocene II-T, synthesis

Campus : Amritapuri

School : School of Biotechnology

Center : Biotechnology, Phytochemistry Labs

Department : biotechnology, Chemistry

Year : 1981

Abstract : Regiospecific syntheses of tritium labelled precocene I (5a) and precocene II (5b), the antijuvenile hormones, have been accomplished. The syntheses involved condensations between 2-hydroxyacetophenones (1) with acetone-T to give cross condensation products 2 which on cyclodehydration furnished 2,2-dimethyl-4-chromanones-(2-gem dimethyl-T) (3). Reduction of 3 with lithium aluminium hydride gave chroman-4-ols (2-gem dimethyl-T) (4). Dehydration of 4 furnished 2,2-dimethyl- chromenes- (2-gem dimethyl-T) (5). Starting with appropriate acetophenones and acetone-T, precocene I (7-methoxy-2,2-dimethylchromene) and precocene II (6, 7-dimethoxy-2, 2-dimethylchromene) labelled with tritium in the 2-gemdimethyl positions, have been synthesised in high chemical as well as radiochemical yields.

Cite this Research Publication : A. Banerji and Goomer, N. C., “Synthesis of tritium labelled precocenes”, Journal of Labelled Compounds and Radiopharmaceuticals, vol. 18, pp. 1737–1741, 1981.

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