Publication Type : Journal Article
Publisher : European Journal of Medicinal Chemistry
Source : European Journal of Medicinal Chemistry, Volume 45, Number 1, p.106 - 113 (2010)
Url : http://www.sciencedirect.com/science/article/pii/S0223523409004632
Keywords : cytotoxicity
Campus : Amritapuri
School : School of Arts and Sciences
Department : Chemistry
Year : 2010
Abstract : The novel glycosyl saccharide derivative, (d-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94×10−8 (LC50=2.76×10−8 for cisplatin) and so distinctly better than free ligand and other complexes.
Cite this Research Publication : M. P. Sathisha, Srinivasa Budagumpi, Dr. Naveen V. Kulkarni, Gurunath S. Kurdekar, V. K. Revankar, and K.S.R. Pai, “Synthesis, structure, electrochemistry and spectral characterization of (d-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice”, European Journal of Medicinal Chemistry, vol. 45, pp. 106 - 113, 2010.