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Total synthesis of a pyrroloindoloquinazoline alkaloid

Publication Type : Journal Article

Publisher : American Chemical Society

Source : Organic Letters, 2013

Url :

Campus : Amritapuri

School : School of Biotechnology

Verified : No

Year : 2013

Abstract : A highly concise stereoselective synthesis of a newly identified alkaloid with a pyrroloindoloquinazoline skeleton has been achieved. To this end, a chiral auxiliary mediated asymmetric acetate aldol reaction on tryptanthrin was explored and the resulting adduct was converted to the product by a novel one-pot reductive cyclization/transamidation using NiCl2·6H2O/NaBH4 in methanol.

Cite this Research Publication : Digvijay Gahtory, Mangilal Chouhan, Ratnesh Sharma, and Vipin A. Nair "Total Synthesis of a Pyrroloindoloquinazoline Alkaloid", Organic Letters 2013, 15, 3942-3945

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