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Triple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumors: Treatment outcomes, response and their determinants

Publication Type : Conference Proceedings

Publisher : National Library of medicine

Source : ESMO Asia 2018. Annals of Oncology (2018) 29 (suppl_9): ix21-ix22, https://doi.org/ 10.1093/annonc/mdy429

Url : https://pubmed.ncbi.nlm.nih.gov/33402572/

Campus : Kochi

School : School of Medicine

Year : 2021

Abstract : Background: Leptomeningeal carcinomatosis (LC) is the metastatic infiltration of leptomeninges by malignant cells originating from an extrameningeal primary tumor site, either extraneural or intraneural. In the absence of treatment, survival is usually measured in weeks, however with treatment this may be extended to a few months. Our institutional protocol has been to offer intrathecal chemotherapy (ITC) to patients having solid tumors with cerebrospinal fluid (CSF) cytology positive leptomeningeal carcinomatosis. This study was performed to describe the oncological outcomes in this cohort and their determinants.

Cite this Research Publication : Srinivasalu V K, Subramaniam N, Philip A, Jose W, Pavithran K (2018) Triple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumours In: ESMO Asia 2018. Annals of Oncology (2018) 29 (suppl_9): ix21-ix22, https://doi.org/ 10.1093/annonc/mdy429

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