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Ultrasonic assisted Fischer Glycosylation: Generating Diversity for Glycochemistry

Publication Type : Journal Article

Publisher : Molecular Diversity

Source : Molecular Diversity, Volume 15, Number 2, p.341–345 (2011)

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Campus : Amritapuri

School : School of Arts and Sciences

Department : Chemistry

Year : 2011

Abstract : In this study ultrasound has been utilised for the Fischer glycosylation using free sugars and sulphuric acid immobilized on silica as catalyst. N-acetyl-d-glucosamine, N-acetyl-d-galactosamine, d-glucose, d-galactose, d-mannose, l-fucose, and lactose were glycosylated with propargyl alcohol or 2-azidoethanol affording the corresponding glycosides, with the production of the $alpha$-glycopyranoside as the dominant product. Remarkable acceleration of the glycosylation reactions (15nbsp;min–2nbsp;h compared to several hours) over reported procedures together with good yields were always observed

Cite this Research Publication : Dr. Nasrin Shaikh, Russo, L., Cipolla, L., and Nicotra, F., “Ultrasonic assisted Fischer Glycosylation: Generating Diversity for Glycochemistry”, Molecular Diversity, vol. 15, pp. 341–345, 2011.

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