Back close

Metformin Encapsulated Biodegradable Chitosan Nanoparticles: A Novel Strategy for Pancreatic Cancer Therapy

Start Date: Thursday, Mar 01,2012

School: School of Nano Sciences

Project Incharge:Dr. Vinoth K. Lakshmanan
Funded by:DST (SERB)
Metformin Encapsulated Biodegradable Chitosan Nanoparticles: A Novel Strategy for Pancreatic Cancer Therapy

Metformin is a frequently used medication for patients with type II diabetes mellitus (DM) that has received increased attention, because of a study from pharmacy and disease databases showing decreased cancer incidence in individuals taking metformin. Metformin inhibits the growth of breast and prostate cancer cell lines. 

In vitro and in vivo experiments showed modest inhibition of tumor growth in breast cancer cell line lacking estrogen, progesterone and HER2 receptors. Metformin has also shown reduced incidence of pancreatic cancer in hamsters and delays onset to mammary ref and other tumors.

Diabetics treated with metformin have reduced cancer risk, although it is unclear whether metformin affects cancer directly or indirectly by inhibiting the diabetic state. The present project is aimed at the development and characterisation of chitosan nanoparticles capable of delivering metformin drug for potential therapeutic application in pancreatic cancer.

Related Projects

Role of Staphylococcal Pathogen Associated Molecular Patterns in Septic Arthritis
Role of Staphylococcal Pathogen Associated Molecular Patterns in Septic Arthritis
Targeted Nanoparticle Photodynamic Therapy
Targeted Nanoparticle Photodynamic Therapy
Thematic Unit of Excellence (TUE) on Tissue Engineering and Medical Bio-Nanotechnology
Thematic Unit of Excellence (TUE) on Tissue Engineering and Medical Bio-Nanotechnology
Nano Toxicology and Nano Medicine – Phase II
Nano Toxicology and Nano Medicine – Phase II
Novel Targeted Chitosan based Therapeutic Polymeric Nanomedicines for Lung Cancer Applications
Novel Targeted Chitosan based Therapeutic Polymeric Nanomedicines for Lung Cancer Applications
Admissions Apply Now