Back close

Modulation of MicroRNA and Transcriptional Regulation of MMP-2 by Natural Products in Human Breast Cancer Cells

Start Date: Wednesday, Aug 01,2012

School: School of Biotechnology

Co-Project Incharge:Prof. Bipin Nair
Funded by:DBT
Modulation of MicroRNA and Transcriptional Regulation of MMP-2 by Natural Products in Human Breast Cancer Cells

India is rich in plant biodiversity, and that has been utilized extensively in traditional medicine. In collaboration with Dr. Asoke Banerji (Phytochemistry, Amrita School of Biotechnology) who is leading the efforts in the extraction and purification of natural products from various plant sources, we plan to test these compounds on the expression of gelatinases (MMP-2 and MMP-9); known to be up-regulated in majority of cancers including breast and colon cancers. MMP-2 and -9 are involved in tumor invasion and metastasis. We are engineering reporter-based cancer cell lines, and designing in vitro assays specifically to test the effect of various natural products on the expression of these two genes.

Related Projects

Screening for Compounds with Lifespan Altering Effect on Caenorhabditis Elegans and Gene Expression Microarray Data Based Computational Drug Repurposing
Screening for Compounds with Lifespan Altering Effect on Caenorhabditis Elegans and Gene Expression Microarray Data Based Computational Drug Repurposing
Isolation, purification, characterization and application of alpha 1,5 endo L-arabinase
Isolation, purification, characterization and application of alpha 1,5 endo L-arabinase
Marine Algae – An Important Source for Lectins
Marine Algae – An Important Source for Lectins
Cost Effective Device and Cloud Enabled Smart Solution for Diabetes Care
Cost Effective Device and Cloud Enabled Smart Solution for Diabetes Care
Development of Heterotrophic and Phototrophic Microbial Fuel Cell
Development of Heterotrophic and Phototrophic Microbial Fuel Cell
Admissions Apply Now