Back close

Proteasome inhibitors from natural products

School: School of Biotechnology

Project Incharge:Dr. Nandita Mishra
Proteasome inhibitors from natural products

The ubiquitin-proteasome system (UPS) plays an essential role in many cellular processes, including cell cycle progression, proliferation, apoptosis and angiogenesis. Proteasome inhibitors like Bortezomib (Velcade, PS-341), has been successfully used as anticancer drug. Several natural compounds, including the green tea polyphenols, microbial metabolite lactacystin and many triterpenes have been shown to be potent proteasome inhibitors. One of our ongoing project is to screen novel proteasomal inhibitors from natural products that induce cell death in cancer cells.

Related Projects

Molecular Mechanisms in Impaired Wound-Healing
Molecular Mechanisms in Impaired Wound-Healing
To strenthen the Post Graduate Teaching and Research Facilities in the department on 50:50 mode being a Private Academic Institution
To strenthen the Post Graduate Teaching and Research Facilities in the department on 50:50 mode being a Private Academic Institution
Biodegradation Of Plastics Using Fungal Isolates
Biodegradation Of Plastics Using Fungal Isolates
Value addition to seabukthorn through isolation & characterisation of pharmacologically active compounds
Value addition to seabukthorn through isolation & characterisation of pharmacologically active compounds
Novel Anti-MRSA Compounds from Padina tetrastromatica: Identification, Isolation and Mass Spectrometric characterization
Novel Anti-MRSA Compounds from Padina tetrastromatica: Identification, Isolation and Mass Spectrometric characterization
Admissions Apply Now