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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : International Journal of Biological Macromolecules
Source : Int J Biol Macromol, Volume 110, p.2-6 (2018)
Keywords : Animals, Drug Delivery Systems, endocytosis, Humans, infection, Macrophages
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2018
Abstract : Intracellular infections are tricky to treat, the reason being the poor penetration of antibiotics/antimycotics into the microbial niche (host cell). Macrophages are primary targets of facultative and obligate intracellular bacteria/fungi to be abused as host cells. The need for drugs with better intracellular penetration led to the development of endocytosable drug carriers, which can cross the cell membrane of the host cells (macrophages) by imitating the entry path of the pathogens. Therefore, the drugs can be targeted to macrophages ensuring enhanced therapeutic effect. This review discusses the exploitation of various nanocarriers for targeted delivery of drugs to the macrophages in the last two decades.
Cite this Research Publication : V. Aparna, Shiva, M., Dr. Raja Biswas, and Dr. Jayakumar Rangasamy, “Biological Macromolecules based Targeted Nanodrug Delivery Systems for the Treatment of Intracellular Infections”, Int J Biol Macromol, vol. 110, pp. 2-6, 2018.