• Bacteriocins are antimicrobial peptides produced by bacteria that kill or inhibit the growth of other bacteria. Bacteriocins differ from most therapeutic antibiotics in being proteinaceous and generally express a narrow specificity of action against strains of the same or closely related species.

  • Enteric pathogens in the sewage are the reason for a variety of diseases throughout the world. Here in this project we use recombinant protein expression as a remedy to kill enteric pathogens present in sewage. One way to kill these pathogens is by degrading their cell walls using cell wall hydrolases like amidase. We isolated the plasmid from the transformed S. aureus with the pTX15 vector containing the amidase, using Qiagen plasmid isolation kit.

  • This research project seeks to bring together biomass based biochars and hydrochars from rice husk waste product to remove heavy metals and other contaminants from industrial and domestic wastewater that makes its way untreated or only partially treated into rivers and streams.

  • To understand neural circuit computations a different approach is needed: elaborate realistic spiking neural networks of the rat cerebellum and use them, together with the theoretical basis of central network computation. This recognition is the goal of this project. The first goal is to extend the cerebellar models to simulate the ensemble network activity. The second is the implementation in robotic simulators and robots to achieve enhanced motor control capabilities. 

  • In a unique partnership, Amrita Vishwa Vidyapeetham joined hands with Wipro Technologies, Bangalore to work on an end-to-end diabetes solution. The project entitled "Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care" is funded by DBT-BIRAC, Government of India.

  • Antibiotic resistance represents a looming public health issue across the globe. Strikingly several medical interventions will increase our vulnerability to infection with antibiotic resistant bacteria. Efforts to minimize fecal–orally transmitted pathogens are inadequate in many developing countries.

  • The main focus was on the biogenic routes for synthesis of silver nanoparticles and it paved the way for the search of new biosources capable to reduce metals to their nano sizes. In this line, like plant, microorganisms like bacteria and fungi have been experimented and proved to be successful. But very few reports are available on the use of endophytic microorganisms for the synthesis of nanoparticles. The present study was focused on the biosynthesis of silver nanoparticles using endophytes, from mangrove plants located at Aayirumthengu mangrove forests on the south west coastal region of Kerala, as a biological alternative to the chemical method. The silver nanoparticle synthesized were confirmed by UV/VIS spectroscopy and were characterized by Dynamic light scattering (DLS) and Transmission electron microscopy (TEM) for the analysis of size. The particles obtained were of size around 100 nm. 

  • Aspergillus niger capable of hydrolyzing naringin by growing the fungi at 280 C, on selective synthetic minimal medium, pH 6, containing 1% naringin was selected for the study. Naringinase enzyme was produced using the production media and the enzyme was precipitated using 60% ammonium sulphate. Purification was done using anion exchange chromatography. Enzyme was characterized in respect to pH and temperature. Application study revealed good results.

  • In comparison to the traditional biochemical tests for identification of bacteria, ribotyping is a high throughput method that enables rapid identification of microorganism. Ribotyping involves isolation of genomic DNA, amplification of 16S rRNA and finally sequencing of the variable region to establish the identity of the organisms. In this project bead beating method for the extraction of DNA is used and the products directly used for PCR amplification without any purification step.

  • Microbil Fuel cell is a bio-electrochemical fuel cell where the anode reaction is controlled by microorganisms. The work was carried out on different exoelectricigens and electrodes that could be more efficient and cheaper than the existing ones. A new soil isolate was used for this study to use as the anode respiratory bacteria and different electrodes were tried. The system showed an improved power generation when used the newly obtained organism with different electrodes.

  • Alpha 1, 5- L endo-arabinase enzyme exhibits a number of industrial and biological applications which includes haze removal in wine and other beverages industry, anti-mycobacterial property, in production of cellulosic ethanol, paper and other food processing industries. The work started with the screening of effective producers of endo arabinase enzyme from different natural sources. We isolated about 78 different fungal isolates from different natural sources and from that through secondary screening we obtained effective 8 organisms which are active producers of endo arabinase enzyme and the enzyme was produced using specific media. Protein was precipitated using ammonium sulphate and purified by anion exchange chromatography. Protein bands were obtained in the 15% SDS gel corresponding to its molecular weight (. Enzyme was characterized and the kinetic study was done. During the study cost effective media was formulated for the production of endo arabinose.

  • The silver nanoparticles (AgNPs) synthesized using leaf extracts as reducing and stabilizing agent are already reported and evaluated for antibacterial activity against drug resistant bacteria isolates. The effect of extract concentration, synthesis time, pH and temperature on the reaction rate and the shape of the Ag nanoparticles are investigated. The nature of AgNPs synthesized was characterized by UV–vis spectroscopy, Dynamic light scattering method and Transmission electron microscopy (TEM). The particle size was estimated around 100 nm. The antibacterial potential of synthesized AgNPs was compared with that of aqueous leaf extracts by well diffusion method. The AgNPs at 0.1-30 μg/ml concentration significantly inhibited bacterial growth against multi drug resistant Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli). The synthesized Ag NPs has been developed by using the fresh leaf extract of Bauhinia Acuminata, Cynodon dactylon, Gracinia cambogia and it showed minimum inhibition activity at 0.5 μl.