• This project is to develop and deploy an integrated real-time landslide monitoring and detection system using emerging wireless sensor network technology. The landslide monitoring and detection system will be used for the prediction of rainfall-induced landslides, in three landslide prone areas in the Himalayas, India. 

    amrita-wireless-sensor-network-for-landslide-detection-system-for-himalayas
  • An indoor information system is a system that gives information about the details of a building such as the different spaces within the building, exits, and their properties and also about other entities in the buildings like utilities, objects like tables, shelves etc.

    indoor-information-representation-and-management-system-iirms-
  • India is rich in plant biodiversity, and that has been utilized extensively in traditional medicine. In collaboration with Dr. Asoke Banerji (Phytochemistry, Amrita School of Biotechnology) who is leading the efforts in the extraction and purification of natural products from various plant sources, we plan to test these compounds on the expression of gelatinases (MMP-2 and MMP-9); known to be up-regulated in majority of cancers including breast and colon cancers.

    modulation-of-microrna-and-transcriptional-regulation-of-mmp-2-by-natural-products-in-human-breast-cancer-cells
  • Investigating the organized activity of neuron ensembles is critical to understand how brain circuits work and is one main target of the project. Reconstruction of network activity has proved to be a hard task. This project will study cellular function using multi-scale models of single cells and networks will be developed with NEURON.

    computational-modelling-and-prediction-of-cerebellar-input-layer-function-timing-and-plasticity-for-understanding-neurophysiological-disorders
  • This study attempts to analyze, in a prospective manner, the psycho-social and economic impact of surgery for CHD on Indian families.

    psychological-and-economic-impact-of-surgery-for-congenital-heart-disease-chd-on-indian-families
  • MicroRNAs (miRNAs) are short double stranded RNAs that are produced endogenously in mammalian cells, and control the regulation of many target genes at the post-transcriptional level. There are many reports of the misregulation of these miRNAs in cancer. We will be studying the regulation of MMP-2 & MMP-9 by miRNAs, and the effect of natural products on the modulation of these miRNAs.

    the-discovery-of-micrornas-mirnas-that-regulate-the-expression-of-gelatinase-a-matrix-metalloproteinase-2-mmp-2-and-b-matrix-metalloproteinase-9-mmp-9-in-colon-cancer-cells
  • In collaboration with the Medical Informatics Group, CDAC Trivandrum, the MEDSIM project will design and develop Computer based Medical Simulations that will allow students pursuing medical sciences to visualize, learn, practise and experience a variety of medical skills and procedures in order to provide a simulated patient experience.

    computer-based-medical-simulation-medsim-
  • Multidrug resistant microbial infections are difficult to treat with common antibiotics, and incidences of infections caused by such strains are increasing day by day. Therefore, there is a constant and urgent need for alternative and effective anti-microbial agents for treatment of poultry, cattle and humans.

    identification-and-characterization-of-anti-microbial-compounds-s-and-adhesins-produced-by-lactobacillus-fermentum-l-fermentum-
  • This proposal seeks to Architect, Design, Develop and deploy a Cross-functional, Multi-Media, Multi-Channel, High Definition, Interactive, Immersive,  Adaptive Classroom experience– a University without walls and borders, that effectively uses the high bandwidth, low latency worldwide network provided by the NKN to enable students attend classes of higher education at eminent national and international universities. The remote classroom solutions today do not provide a really immersive environment to captivate and motivate the students. The students tend to get tired after short sessions. By providing a really interactive and immersive experience, we hope to open up a totally new paradigm in remote classrooms and discussion rooms.

    national-knowledge-network-nkn-a-gateway-to-global-classroom
  • Studies on structural modifications of antimicrobial chitosan (Rs. 10,000, funded by Kerala State Science, Technology and Environment for a period of one year from July 2012 to June 2013).

    structural-modifications-of-antimicrobial-chitosan
  • This project proposes to explore the utility of the autologous modified endothelial cells engrafted onto a nano scaffold framework as a novel therapeutic modality for optimising wound healing. This would lead to potential translational application in patients with diabetic foot ulcers and non-healing wounds.

    development-of-blood-outgrowth-endothelial-cell-and-nanofiber-scaffold-synergy-in-wound-healing
  • Rheumatoid arthritis is a chronic, progressive systemic inflammatory disease of the synovium, a delicate membrane that lines the non-weight-bearing surfaces of the joint. Auto-immunity plays an important role in the development of RA and that increased antibody response has been shown to be a hallmark of RA. Presence of anti-CCP and anti-immunoglobulin reactivity indicates that antibody response is crucial in the development of RA.

    identification-of-new-autoantigens-in-rheumatold-arthritis-using-an-unbiased-clinical-proteomics-approach
  • Staphylococcus aureus is the commonly found bacteria in septic arthritis. Methicillin resistant S.aureus (MRSA) is the most common cause of community-onset adult septic arthritis. It has been documented that S.aureus cell surface associated components can induce sepsis, organ injury, and septic arthritis. 

    role-of-staphylococcal-pathogen-associated-molecular-patterns-in-septic-arthritis
  • Synthesis and preliminary evaluation of ring – A mono – substituted chalcones as potential anti-inflammatory agents ( funded by Kerala State Council for science, Technology and Environment (KSCSTE) for a period of one year from July 2012 to June 2013 to the extent of Rs. 10,000/-)

    synthesis-and-preliminary-evaluation-of-ring
  • The project titled Fault diagnosis of dynamic mechanical systems (gearbox) based on signal processing using machine learning techniques, is funded by DRDO. The investigators of the project are Dr. K. I. Ramachandran, Dr. M. Saimurugan, Dr. K. Rameshkumar and Mr. P. Krishnakumar.

    fault-diagnosis-of-dynamic-mechanical-systems-gearbox-based-on-signal-processing-using-machine-learning-techniques-
  • The project titled "Development of Spinodal bronze, Bronze Matrix Composite and Functionally Gradient Bronze and Comparison of their Mechanical and Wear Properties", is funded by DRDO. 

    development-of-spinodal-bronze-bronze-matrix-composite-and-functionally-gradient-bronze-and-comparison-of-their-mechanical-and-wear-properties
  • One main issue for cerebellum-based robotic models is to understand information processing in the cerebellar circuit in order to reproduce artificial networks able to perform analogous tasks in robotic control systems. Critical to this aim is the investigation of timing mechanisms in the cerebellar cortex.

    neurophysiological-recording-and-modeling-fast-response-timing-of-granule-and-golgi-cell-responses-for-cerebellar-function
  • Endovascular stents, used commonly for the treatment of occlusive vascular diseases, have historically been manufactured using metals and metal composites. Although stents have reduced the restenosis rate from 40% to 20% compared to angioplasty alone, in-stent restenosis still remains a major limitation for this approach.

    nanosurface-engineering-of-bare-metallic-coronary-stents-for-combating-in-stent-restenosis
  • The project titled "Investigation of compatibility between portland pozzolana cement and admixtures in high performance concrete ", is funded by DST. The investigator of the project is Dhanya Sathyan.

    investigation-of-compatibility-between-portland-pozzolana-cement-and-admixtures-in-high-performance-concrete
  • Manganese dioxide (MnO2) is a technologically important material and has been extensively studied due to its potential uses in non-volatile memory devices, gas sensors and batteries. The construction of aligned ensembles of these metal oxide nanostructures as electrodes could advance their existing potential in supercapacitor applications.

    nano-fibre-scaffold-electrodes-based-on-mn02-and-polymer-carbon-composites-for-high-performance-storage-device
  • Envenomation resulting from snake bite is a significant problem faced by both developed and developing countries. Within South Asia, India is quite heavily affected with an estimated 46,000 deaths per year. Currently available anti-venom therapy consists of polyvalent immunoglobulin fractions prepared from the plasma of donor animals, typically horses or sheep that were immunized with a mixture of venoms from different snake species.

    development-of-peptide-inhibitors-against-functional-components-of-snake-venom-a-new-approach
  • Metformin is a frequently used medication for patients with type II diabetes mellitus (DM) that has received increased attention, because of a study from pharmacy and disease databases showing decreased cancer incidence in individuals taking metformin. Metformin inhibits the growth of breast and prostate cancer cell lines. 

    metformin-encapsulated-biodegradable-chitosan-nanoparticles-a-novel-strategy-for-pancreatic-cancer-therapy
  • A tropical forest, with its varied life forms, provides an array of resources and services, making life possible on earth. The major beneficial components include food, medicine, clothing and shelter. Plants used in medicine needs much attention as, on one side, they are not fully explored for their medicinal and curative properties, and on the other side, some of them are threatened by habitat loss and over exploitation.

    inventory-of-vegetation-with-special-reference-to-medicinal-and-aromatic-plants-and-documentation-of-traditional-knowledge-in-the-walayar-valley-western-ghats
  • Lactobacillus fermentum, a probiotic strain, which the team isolated from human colonic mucosal biopsy samples, possesses anti-microbial activities and inhibits the adhesion of enteropathogens to intestinal epithelial cells. Isolated cell surface associated proteins from L. fermentum were sufficient for this adhesion exclusion. Identification and characterisation of these surface proteins from L.

    identification-and-functional-analysis-of-probiotic-bacterial-surface-associated-proteins-in-preventing-enteropathogenic-infections
  • A large number of organo-bridged dicobaloximes, PyCo(L2)-R-Co(L2)Py, have been reported in the literature. Ligand-bridged complexes are of interest in view of their role as reaction intermediates in innersphere electron transfer processes. Nitrogen heterocycles are extensively used as bridging ligands in coordination and metallosupramolecular chemistry.

    synthesis-characterization-and-liquid-crystalline-studies-of-1-3-bis-4-pyridyl-propane-bridged-dicobaloximes
  • As wireless sensor networks (WSN) are emerging worldwide, the lack of e-learning facilities degrades the availability and usage of WSN applications, mainly in universities. The Remote Triggered Wireless Sensor Network Lab aims in providing an easy, efficient, interactive and user friendly environment to the students, researchers etc., which can trigger their inquisitiveness and give them the equipments and materials needed for the lab experiments which are shared to them in a virtual manner wherein they can conduct the experiments online and observe the outputs as in a real lab through an effective visualisation tool.

    remote-triggered-wireless-sensor-network-lab
  • The project titled "Lab-on-a-chip(LOC) for the monitoring of diabetes, cholesterol and kidney function" is funded by DBT, Govt. of India. Dr. Bipin Nair is the Principal Investigator of the project.

    lab-on-a-chip-loc-for-the-monitoring-of-diabetes-cholesterol-and-kidney-function
  • The project aims at high through put screening of biological activity of extracts from deep sea marine organisms.The project is funded by MLR Technology Development (MLR-TD), Marine Living Resources Program (MLRP), Ministry of Earth Sciences.

    extracts-from-deep-sea-marine-organisms
  • Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which originate from the intrinsic nature of the enzymes. This project aims at developing a commercially viable non-enzymatic glucose sensor strip and a glucometer. Electrode surface modified with transition metal and metal oxide nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. 

    development-of-non-enzymatic-electrochemical-glucose-biosensors-and-glucometer
  • This project deals with development of nanomedicine for the targeted photodynamic therapy of cancer. This project is done in collaboration with Erasmus Medical Centre, Netherlands, where pre-clinical evaluation will be done using the nanomedicine developed by the ACNS team.

    targeted-nanoparticle-photodynamic-therapy
  • The project titled "Robust Features for Speaker Verification" is funded by TCS. Dr. C. Santhosh Kumar, Dr. K. I. Ramachandran are the investigators of the project.

    robust-features-for-speaker-verification
  • Lentiviral vectors are powerful tools to deliver genetic material into almost any cell or tissue, and are useful even in the creation of transgenic animals. They have been shown to deliver foreign genes not only to mammalian cells, but also in cells derived from fish, birds and amphibians. We are collaborating with InStem/NCBS to generate transgenic primitive metazoans.

    lentiviral-vectors-for-the-creation-of-transgenic-organisms
  • As with computing systems, trends show sharp increase in more and more electronic devices and appliances networked to the internet. From simple home appliances to more complex systems such as medical devices and industrial control (SCADA) systems, there is an integration of software and hardware that causes new security threats due to its contact to the internet.

    security-of-the-internet-of-things
  • Berberine, an isoquinoline alkaloid with a bright yellow color, is easily seen in most of the herb materials when found in significant amounts. Among Chinese herbs, the primary sources for berberine are phellodendron and coptis. Similar isoquinoline alkaloids (jateorrhizine, coptisine, palmatine, and columbamine) in these two herbs also have a yellowish color.

    synthesis-of-intermediate-analogues-for-biologically-active-molecules
  • Prognosis and diagnosis are important aspects of any state-of-the-art aerospace application. Machine condition based monitoring and maintenance can help enhance the system performance and prevent system failures. It also helps reduce maintenance costs. Line replaceable units (LRU) are the basic components in any aerospace system that can be easily replaced during maintenance.

    scalable-fault-models-for-prognosis-and-diagnosis-of-generators-in-aircraft-electrical-systems
  • Several projects are focused on the development of nanomedicines for application in cancer therapeutics, drug delivery for infectious diseases and also for regeneration of tissues using nanostructured scaffolds. Some of the tissues studied are bone, cartilage, cardiac tissue, vascular tissue and liver tissue. A wide range of natural polymeric nanostructured materials and bioceramics are being investigated for such applications.

    nanomedicine-and-tissue-engineering
  • The project proposes to extend the nano-toxicological investigations of developed multifunctional NPs. It aims to extend the previous study to develop new theragnostic nanomedicines.

    nano-toxicology-and-nano-medicine-phase-ii
  • In 2011, Amrita Center for Nanosciences and Molecular Medicine was chosen for a TUE in Tissue Engineering and Medical Bio Nanotechnology by the Nanomission of the Government of India. The TUE focuses on translational biomedical products where nanomaterials play an enabling role. This includes nanomedicines using organic non-toxic encapsulants, surface modified products, multifunctional diagnostic nanoparticles, and tissue engineered implants.

    thematic-unit-of-excellence-tue-on-tissue-engineering-and-medical-bio-nanotechnology
  • Bronze alloys (Cu-Sn) are widely used as bearing materials in aircrafts, automobiles, machine tools, and general engineering applications such as dies for plastic injection molding. However, they are in use for a long time in wrought and cast forms, without enhancing their strength and hardness.

    development-of-bronze-alloys-and-comparison-of-their-mechanical-and-wear-properties
  • Induced pluripotent stem cells (iPSc) are somatic cells that have been reprogrammed to a pluripotent state. These iPSc have similar characteristics to embryonic stem cells and hold great promise in various aspects of research. The aim of this study is to develop patient specific stem cells to understand disease mechanism and identify drugs that will prevent malignant transformation.

    generation-of-induced-pluripotent-stem-ips-cells-from-genetically-altered-somatic-cells
  • This study involves the development of a nutraceutical product using coconut water as the main ingredient by incorporating some of the traditionally used natural antioxidants, such as, extracts from plants like Trichopus, Sp.Carrot, Grape seed. etc, without affecting stability. The research involves characterization of taste, anti-oxidant potential and stability of a variety of different formulations.

    nutraceutical-preparation-using-coconut-water
  • This project deals with nano-toxicological evaluation of silica nano-particle based agricultural products such as neutraceuticals and pesticides.

    toxicology
  • This project aims at understanding cognitive functioning of cerebellar input layer and implement signal processing abilities into neural hardware using cerebellar architecture. The main goals include understanding cerebellum granule neuron’s role in signal propagation and information processing in a central neuronal network. The other major focus will be on the analysis of cerebellar microcircuits for designing electronic neural processors.

    bio-inspired-processor-design-for-cognitive-functions-via-detailed-computational-modeling-of-cerebellar-granular-layer
  • As part of the India 4 EU program, Dr. Zeena S. Pillai, Department of Chemistry, Amrita School of Arts and Sciences, had the opportunity to work at the University of Bologna in Italy for two months from June 2011-July 2011. The collaborative research was on Photophysical and Co-ordination Properties of Cyclam Core Dendrimers. They selected dansylated dendrimers with cyclam core and studied its complexation properties with lanthanides.

    photophysical-and-co-ordination-properties-of-cyclam-core-dendrimers
  • This project is an observational, prospective and laboratory based retrospective multi-centre, national study of invasive disease caused by S.Pneumoniae or H.influenzae or N. meningitis in children < 5 years of age. Two aspects are covered: one, a study of disease burden indicators and, two, study of the organism characteristics covering a well defined population in a specific geographical area.

    population-survey-of-invasive-diseases-in-india-caused-by-s-pneumoniae-or-h-influenzae-or-n-meningitis-in-children-below-5-years-of-age
  • Visual cryptography is a perfectly secure way to protect secrets and is characterized by its decryption method. This project is to develop new visual cryptographic scheme satisfying certain conditions. In this project, a secret image is split into a set of shares, so that some authorized shares can have access to the secret, where as other unauthorized shares cannot leak out any secret information.

    development-of-visual-cryptographic-schemes
  • The primary objective of the project is to develop soft, compliant, lead-free, low-melting-temperature solder materials by electrodeposition. These materials are candidates to replace lead-tin alloys in flip-chip technology for microelectronic packaging.

    Specifically, the goals are:

    electrodeposition-of-lead-free-solder-materials-for-microelectronic-packaging
  • The Online Labs is an educational initiative pioneered by AmritaCREATE, the Amrita Center for Research in Analytics & Technologies for Education at Amrita Vishwa Vidyapeetham in partnership with CDAC, Mumbai; under a research grant from the Department of Information Technology, Government of India.  

    online-labs-olabs-for-school-lab-experiments-interactive-simulations
  • In the conventional power supply scenario, the electric power feeders in different areas are manually switched off when the demand goes above the scheduled supply. This causes immense revenue loss to the utilities besides discomfort to the consumers. Grid integration of intermittent and uncontrolled generation schemes like wind farms makes the situation worse with conventional power system control.
      

    energy-management-on-smart-grid-using-embedded-systems
  • The project proposes to enhance the technology used, looks to provide a more comprehensive system, and expand the knowledge of landslides and their detection. This project deals with enhancing and deploying integrated landslide monitoring and detection systems using the emerging wireless sensor network technology to predict rainfall induced landslides in landslide-prone areas of India.

    monitoring-and-detection-of-rainfall-induced-landslide-using-an-integrated-wireless-network-system

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