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Unit 1

Introduction: Bulk properties, Surface properties and characterization – polymers, silicone biomaterials, medical fibres and biotextiles – Smart polymers – bioresorbable and bioerodible materials – natural materials, metals and ceramics – physicochemical surface modification.

Biocompatibility concepts: Introduction to biocompatibility – cell material interaction – types of materials – toxic, inert, bioactive – long term effects of materials within the body – cell response.

Unit 2

Chemical and biochemical degradation of polymers – degradation of metals and ceramics – calcification of biomaterials.

Host reactions and their evaluation: Inflammation and foreign body response – adaptive immunity – systemic toxicity and hypersensitivity – blood coagulation and blood materials interactions – device related infections.

Unit 3

Biological testing of biomaterials: Invitro and invivo assessment of tissue compatibility – evaluation of blood materials interaction – microscopy in biomaterials.

Practical aspects of biomaterials: Bioelectrodes, biomedical sensors and biosensors – sterilization of implants – implant failure – implant retrieval and evaluation – legal aspects, ethical issues and regulation aspects.

Text Books

  • Buddy D Ratner, Allan S Hoffman, “Biomaterials Science – An introduction to materials in Medicine”, Elsevier academic press, (2004).


  • Jonathan Black, “Biological Performance of Materials: Fundamentals of Biocompatibility”, 4th edition, CRC Press, (2006).
  • John D. Enderle, Susan M. Blanchard, Joseph D. Bronzino, “Introduction to Biomedical Engineering”, 2nd edition, Elsevier Academic Press, 2005.

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