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The primary research focus of the AMR lab at The AMRITA School of Biotechnology is on combating Antimicrobial Resistance using multiple approaches:

  • Identification and characterization of novel anti-microbials targeting virulence
  • Isolation, characterization and application of bacteriophages or cocktails of phages for environmental as well as potential clinical use – Phage Therapy
  • Mutational analysis of the AMR genes of Gram-negative nosocomial pathogens 
  • CRISPR-Cas9 based solutions to combat antibiotic resistance
  • Understanding Persistence and its role in antimicrobial resistance (AMR)
  • Studying the inter-relationship between virulence and antimicrobial resistance
  • Characterization of the filamentous (Pf) phages in regional clinical isolates of P. aeruginosa
  • Design and development of Point-of-Care diagnostics for early detection
  • Surveillance of sewage samples to study the emergence of antimicrobial resistance patterns using metagenomics, meta transcriptomics and metabolomic approaches coupled to AI/ML tools/algorithms
  • Development of host-directed therapies
  • AI/ML strategies to predict emerging patterns of resistance

Starting in 2018, the Antimicrobial Resistance lab has been collaborating with the Tata Institute for Genetics and Society (TIGS) to combat MDR gram-negative pathogens. Our current focus is the characterization of bacteriophages and genome editing strategies to target MDR Pseudomonas aeruginosa, which is classified as a critical priority pathogen by WHO.

Keywords: Biofilims, Quorum Sensing, Phage Therapy, Genome Editing, AI

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