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Our research is primarily focused on combating Antimicrobial Resistance using multiple approaches:

  • Screening Natural Products that can function as anti-quorum sensing agents and elucidating their mechanism of action
  • Isolation, characterization and application of bacteriophages or cocktails of phages for environmental as well as potential clinical use – phage therapy
  • Mutational analysis of the AMR genes of Pseudomonas aeruginosa
  • Phage-mediated gene drive using CRISPR-Cas9 to target the AMR genes of pathogens
  • Understanding Persistence and its role in antimicrobial resistance (AMR)
  • Studying the inter-relationship between virulence and antimicrobial resistance

Starting in 2018, the Antimicrobial Resistance lab has been collaborating with the Tata Institute for Genetics and Society (TIGS) to combat MDR gram-negative pathogens. Our current focus is the characterization of bacteriophages and genome editing strategies to target MDR Pseudomonas aeruginosa, which is classified as a critical priority pathogen by WHO.

Keywords: Biofilims, Quorum Sensing, Phage Therapy, Genome Editing, AI

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