Unit I (10 Hours)
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility pa- rameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, dif- fusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. Partiallymiscible liquids, Critical solution tempera- ture and applications. Distribution law, its limitations and applications
Unit II (10 Hours)
States of Matter and properties of matter:State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solidcrystalline, amorphous & polymorphism. Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment, disso- ciation constant, determinations and applications
Unit III (09 Hours)
Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, sur- face active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.
Unit IV (08 Hours)
Complexation and protein binding: Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and ther- modynamic treatment of stability constants.
Unit V (08 Hours)
pH, buffers and Isotonic solutions: Sorensen’s pH scale, pH determination (electrometric and calorimet- ric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.