<p>A moving image is aligned with a fixed image by an initial gross alignment, followed by identification of particular regions or blobs in the moving image. The blobs may be selected based upon particular features in regions of the image, such as anatomical features in a medical image. Blob matching is performed between the selected blobs and the fixed image, and transforms are developed for displacement of the matched blobs. Certain blobs may be dropped from the selection to enhance performance. Individual transformations for individual pixels or voxels in the moving image are then interpolated from the transforms for the blobs.</p>
R. Mullick, Nagaraj, N., and Poston, T., “Image Registration System and Method”. 2006.