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Cancer Biology

Our laboratory studies the process of cell death. Upon the exposure of different kind of stress (like UV Radiation, Starvation, Xenobiotics etc) the cell takes on various death pathways like Apoptosis, Autophagy, Necrosis. Apoptosis has been the far and widely studied cell death pathway with membrane blebbing, activation of caspases and cellular and nuclear fragmentation. Recent studies on cell death shows the emergence of several non apoptotic pathways like Paraptosis, Pyroptosis, Ferroptosis etc.



Our research focus is to screen molecules with anti-cancer properties and understand their mode of action with respect to cell death. Many cancer cells are apoptosis resistant; we are trying to target them by an alternative cell death pathway known as “paraptosis” or cytoplasmic vacuolation mediated cell death.We are also interested in the studies of protein homeostasis and cell death in case of neuronal and pancreatic cells.
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Dr. Sanjay Pal Dr. Nandita Mishra
Cancer Biology,
School of Biotechnology
Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P.O.
Kollam – 690525, Kerala, India


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