About Cancer Biology

Our laboratory studies the process of cell death. Upon the exposure of different kind of stress (like uv radiation, starvation, xenobiotics etc) the cell takes on various death pathways like Apoptosis, Autophagy, Necrosis. Apoptosis has been the far and widely studied cell death pathway with membrane blebbing, activation of caspases and cellular and nuclear fragmentation. Recent studies on cell death shows the emergence of several non apoptotic pathways like Paraptosis, Pyroptosis, Ferroptosis etc.

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Research

Our research focus is to screen molecules with anti-cancer properties and understand their mode of action with respect to cell death. Many cancer cells are apoptosis resistant; we are trying to target them by an alternative cell death pathway known as “paraptosis” or cytoplasmic vacuolation mediated cell death.We are also interested in the studies of protein homeostasis and cell death in case of neuronal and pancreatic cells. We are also trying to understand the biology of the extracellular matrix (ECM) in health and disease relevant to India with special reference to malnutrition. Focus is on cell adhesion protein fibronectin and its interaction with different cell surface proteins from both host (MMP-2, heparin, collagen) and guest [fibronectin/collagen binding proteins (FBP /CBP) from microbes].

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Testimonials

Amrita Vishwa Vidyapeetham has a major role to play in transforming our society into a knowledge society through its unique value-added education system

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Dr. A.P.J. Abdul Kalam
Former President of India

This is not just another academy, but a very high quality,world-class institution, focusing on technology research, dealing with very concrete issues which have immediate applications

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Prof.Muhammad Yunus
Nobel Laureate

What makes Amrita students special? Western science leads to knowledge. Eastern sceince leads to understanding. Amrita has both Western and Eastern traditions in education.

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Dr. Lee Hartwell
Nobel Laureate

Reach Us

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Dr. Sanjay Pal / Dr. Nandita Mishra
Cancer Biology,
School of Biotechnology
Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana P.O.
Kollam - 690525, Kerala, India

+91(0)-476-2803124
+91(0)-476-2899722
sanjaypal@am.amrita.edu
nanditamishra@am.amrita.edu

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