Unit I (10 Hours)
Introduction to Biopharmaceutics
Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes.
Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plas- ma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs
Unit II (07 Hours)
Elimination: Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs
Bioavailability and Bioequivalence:Definition and Objectives of bioavailability, absolute and relative bio- availability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.
Unit III (10 Hours)
Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment models, Non com- partment models, physiological models, One compartment open model. (a). Intravenous Injection (Bolus) (b). Intravenous infusion and (c) Extra vascular administrations. Pharmacokinetics parameters - KE ,t1/2,- Vd,AUC,Ka, Clt and CLR- definitions methods of eliminations, understanding of their significance and application
Unit IV (10 Hours)
Multicompartment models: Two compartment open model. IV bolus Kinetics of multiple dosing, steady state drug levels, calculation of loading and mainetnance doses and their significance in clinical settins.
Unit V (07 Hours)
Nonlinear Pharmacokinetics: a. Introduction, b. Factors causing Non-linearity. c. Michaelis-menton method of estimating parameters, Explanation with example of drugs.