Qualification: 
Ph.D, MSc, B.Ed.
bh_nanjundareddy@blr.amrita.edu

Dr. B. H. Nanjundareddy currently serves as Assistant Professor (Selection Grade) at the Department of Chemistry, School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru campus. His Ph.D. thesis is titled “Synthesis and Characterization of Modified Nanoclay Biocomposites for Drug Delivery and Antimicrobial Activity” at Tumkur University. His research interest includes Polymers, Biocomposites, Nanocomposites and Nanomaterials.

Education

  • 2019: Ph.D. in Chemistry
    Tumkur University, Karnataka
  • 1994:  M.Sc. in Chemistry,
    Bangalore University
  • 2009: M. Phil. in Polymer Science
    S. K. University Anatapur, Andra Pradesh
  • 1990: B.Ed. in Physics, Mathematics
    Bangalore University
  • 1988: B.Tech./B.Sc  PCM
    Bangalore University

Professional Appointments

Year Affiliation
Assistant Professor (Selection Grade) (Since 2008) School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru

Publications

Publication Type: Journal Article

Year of Publication Title

2018

B. H. N. Reddy, Rauta, P. Ranjan, and V., V., “Synthesis and characterization of novel SA-PA-LSA/C-30B/AG nanocomposites for swelling, antibacterial, drug delivery, and anticancer applications”, Journal of Applied Pharmaceutics, vol. 10, no. 3, 2018.[Abstract]


The objective of this study was to develop, formulate and evaluate the sodium alginate grafted poly (acrylamide-co-acrylic acid/cloisite-30B/silver nanoparticle hydrogel composites (SA-PAAm-PAAc/C30B/AgNPs) with varying weight percentage (wt %) of cloisite-30B clay for paclitaxel targeted delivery and anticancer activity.

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2018

B. H. N. Reddy, Rauta, P. Ranjan, Venkatalakshimi, V., and Sreenivasa, S., “Synthesis and characterization of cloisite-30B clay dispersed poly (acryl amide/sodium alginate)/AgNp hydrogel composites for the study of BSA protein drug delivery and antibacterial activity”, Materials Research Express, vol. 5, p. 025403, 2018.[Abstract]


The aim of this research is to inspect the effect of Cloisite-30B (C30B) modified clay dispersed poly (acrylamide-co-Sodiumalginate)/AgNp hydrogel nanocomposites (PASA/C30B/Ag) for drug delivery and antibacterial activity. A novel hydrogel composite based sodium alginate (SA) and the inorganic modified clay with silver nano particle (C30B/AgNps)polymer hydrogel composites are synthesized via the graft copolymerization of acrylamide (AAm) in an aqueous medium with methylene bisacrylamide (MBA) as a crosslinking agent and ammonium per sulfate(APS) as an initiator. The UV/Visible spectroscopy of obtained composites is successfully studied, which confirms the occurrence of AgNps in the hydrogel composites. And the swelling capacity and bovine serum albumin (BSA) protein as model drug delivery study for these hydrogel nanocomposites have been carried out. The C30B/Ag filled hydrogel composites exhibit superior water absorbency or swelling capacity compared to pure samples and it is establish that the formulations with clay (C30B) dispersed silver nanocomposite hydrogels show improved and somewhat faster rate of drug delivery than other formulations(pure systems) and SEM and TEM reports suggests that the size of AgNps in the composite hydrogels is in the range of 5–10 nm with shrunken surface and the antibacterial characterizations for gram positive and gram negative bacteria are carried out by using Streptococcus faecalis (S. Faecalis) and Escherichia coli (E.coli) as model bacteria and the hydrogel composites of PASA/C30B/Ag shows exceptional antibacterial activity against both the bacteria as compared to pure hydrogel composites samples.

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2018

B. H. N. Reddy, Rauta, P. R., V. Lakshmi, V., and Sreenivasa, S., “Development, formulation, and evaluation of sodium alginate-g-poly (Acryl amide-co-acrylic acid/cloiste-30B)/agnps hydrogel composites and their applications in paclitaxel drug delivery and anticancer activity”, International Journal of Applied Pharmaceutics, vol. 10, pp. 141-150, 2018.[Abstract]


Objective: The objective of this study was to develop, formulate and evaluate the sodium alginate grafted poly (acrylamide-co-acrylic acid/cloisite-30B/silver nanoparticle hydrogel composites (SA-PAAm-PAAc/C30B/AgNPs) with varying weight percentage (wt %) of cloisite-30B clay for paclitaxel targeted delivery and anticancer activity. Methods: Polymer hydrogel composites of different wt % of cloisite-30B modified clay dispersed sodium alginate (SA) grafted polyacrylamide-co-polyacrylic acid were prepared via in situ free radical initiation polymerization reaction technique. In vitro release of paclitaxel (PT) anticancer drug and anticancer studies were performed. The formulations were further evaluated for swelling, drug encapsulation, drug delivery, anticancer activity study, Fourier transforms infrared spectroscopy (FT-IR), thermogravimetric (TGA), differential scanning calorimeter (DSC) and x-ray diffraction (XRD) characterizations. Results: FT-IR spectroscopy of various composite hydrogel formulations displayed good compatibility between sodium alginate, polyacrylamide, and polyacrylic acid polymers. The thermal study reveals that the formulations with clay (C30B) and AgNPs in hydrogel composites exhibit good thermal stability and less % of weight loss (wt. loss) compared to pure formulations. Further, the highest encapsulation efficiency was shown by the formulation S0-0+D (72.66±5.92%) and least encapsulation efficiency was shown by S75Ag+D (41.33±3.12%) compared to rest of the formulations and S50Ag+D and S75Ag+D samples exhibits relatively slightly higher and sustained cumulative release rate of PT drug at an average rate of 80±9 % within 72 h and also shows relatively better anticancer activity compared to other formulations. Conclusion: Formulations S50Ag+D and S75Ag+Dwere found to be best formulations with a higher cumulative percentage of PT drug release and showed better anticancer activity. © 2018 The Authors.

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2018

B. H. N. Reddy, Raut, P. R., Venkatalakshimi, V., and Sreenivasa, S., “Synthesis and characterization of novel SA-PA-LSA/C-30B/AG nanocomposites for swelling, antibacterial, drug delivery, and anticancer applications”, Asian Journal of Pharmaceutical and Clinical Research, vol. 11, pp. 329-338, 2018.[Abstract]


Objective: The main objective of this work was to formulate and evaluate Closite-30B/nanoAg filled hydrogel composites which are further intentended to be used for the study of drug delivery,antibacterial, and anticancer activity Methods: In this study, Cloisite-30B (C-30B) clay dispersed biopolymer sodium alginate (SA)-grafted-poly (acrylamide [AAm]-co-lignosulfonic acid) hydrogel composites were synthesized by free radical in situ polymerization reaction technique using SA, AAm, and lignosulfonic acid biopolymers in different proportions in combination. which are subjected to invitro drug delivery and Minimum inhibitory concentration(MIC) method for antibacterial activity study by using Streptococcus faecalis (S.faecalis) and Escherichia coli (E. coli)bacteria. The biocompatibility of the prepared gels were determined by standard protocol HaCaT-cells and MCF-7 cell lines further the prepared hydrogel composites were characterized for particle size,encapsulation efficiency,swelling properties,compatibility studies by FTIR etc. Results: The formulated hydrogels were characterized by X-ray diffraction (XRD) to analyze the particles size and crystallinity. The presence of functional groups and their chemical interaction with the drug, C-30B, and silver nanoparticles (AgNPs) were confirmed by the FTIR spectroscopy. Furthermore, the presence of AgNPs in the matrix was confirmed by ultraviolet/visible spectroscopy. Thermogravimetric analysis was performed to find out the thermal degradation, thermal stability, and the percentage of weight loss at various temperatures. Swelling studies revealed that C-30B and AgNPs induced composites exhibited higher swelling ratio than pure hydrogels. The hydrogels with C-30B/AgNPs displayed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria. Further, these hydrogel composites were loaded with the drug paclitaxel (PT), and drug release study showed that the sustained release of the drug from C-30B/Ag hydrogel matrix compared to rest of other samples. Hydrogel composites were cytocompatible in nature (with HaCaT cells) and the cell viability decreased (with MCF-7cells) with the presence of lignosulfonic acid as well as C-30B and AgNPs in the samples as evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide to its insoluble formazan assay. Conclusion: The synthesized hydrogel composites were successfully characterized and eavaluated for sustained release of paclitaxel drug delivery at different pHs and temperatures and it is found that C30B/Ag filled composites exhibits contolled release of drug with higher rate, especially at lower pH (pH2) and higher temperature (37oC) and the same formulations which exhibits better anitbcterial and anticancer activity compared to the virgin samples So the prepared C30B/AgNPs hydrogels composites used in drug dlivery for the effective treatment of cancer and used against bacterias and cancerous cells. © 2018 The Authors.

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2017

B. H. N. Reddy, Dr. T. M. Mohan Kumar, and Lakshmi, V. V., “Synthesis and characterization of sodium alginate stabilized nano-ZnO impregnated into bentonite clay”, Journal of Bionanoscience, vol. 11, pp. 59-65, 2017.[Abstract]


Nanocrystalline ZnO (n-ZnO) particles are synthesized by in-situ sol-gel method, stabilized using sodium alginate (SA) polymer and impregnated into bentonite (Bt) clay matrix by one pot synthesis. Different nanocomposites of n-ZnO are prepared by alkaline hydrolysis of zinc acetate as precursor by varying the concentration of sodium hydroxide. The effect of Bt on the characteristics of n-ZnO was studied. The average particle size of n-ZnO was calculated to be 14-23 nm by XRD analysis which is matching with the TEM values. TEM images clearly showed the influence of Bt on the shape of particles in which 45SA showed ZnO nanorods due to the stabilization effect of SA. Whereas, spherical ZnO nanoparticles are exhibited by 45SA-Bt due the restriction of n-ZnO growth by the interlayers of Bt. We found that the nanocomposites exhibited excellent bacterial resistance towards both Gram negative (E. coli) and Gram positive (S. aureus) bacteria. The bacterial resistance of nanocomposites is slightly more than that of pure n-ZnO. The results of this study proved that the synthesized n-ZnO and its nanocomposites can be used for various application such as antibacterial, semiconducting etc. More »»

2016

B. H. N. Reddy, Lakshmi, V., R, V. Mahesh K., Mylarappa, M., Raghavendra, N., and T., V., “Preparation of chitosan/different organomodified clay polymer nanocomposites: studies on morphological, swelling, thermal stability and anti-bacterial properties”, Nanosystems: Physics, Chemistry, Mathematics, pp. 667-674, 2016.[Abstract]


In the current study, chitosan films were prepared by dispersing different commercially-modified nanoclays, such as C-Na, C-10A, C-15A, C-30B, and C-93A. The exfoliation and morphology were studied using XRD and SEM. The C-15A, C-30B and C-93A nanoclays/Cts BNCs (Bionanocomposites) showed very good uniform exfoliation compared to that of other clays. The thermal analyses were evaluated using DSC and TGA. These results also confirmed that because of exfoliation, the thermal properties were improved in the case of C-15A, C-30B and C-93A nanoclays/Cts BNCs. The swelling capacity of a chitosan/clay films were studied. Increasing the chitosan content in the film increased the swelling capacity significantly; the decreasing order of swelling capacity of Cts/Clay films is in accordance with the decrease in clay content. Greater swelling capacity is shown by films Cts, C-Na and C-10A is because of the presence of greater hydrophilic agencies in the film makeup, which assist in improving the swelling characteristics of the films. The antibacterial activities of Cts/clay were also investigated against Gram-negative and Gram-positive bacteria (E. coli and S. aureus) according to the zone of inhibition in the disc diffusion method.

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2015

B. H. N. Reddy and Mahesh, K. R. Vishnu, “Effect of Particulate Fillers on the Mechanical, Thermal, Moisture and Fire Performance of Unsaturated Isopthallic Polyester/Glass Fibre Reinforced Polymer Composites”, Advances in Polymer Science and Technology: An International Journal, vol. 5, pp. 11–17, 2015.[Abstract]


The fly ash and talc powder produced from the various industrial activities will be hazardous material for the environment. The waste should be used carefully to eliminate environmental pollution. The objective of this research was to investigate the mechanical, thermal, moisture and fire performance of the fly ash and talc dispersed glass fibre reinforced unsaturated polyester composites. The unsaturated polyester composites were made by using a press mold method for 0, 20, 40, 60, 80, and 100 % of fly ash and talc content (w/w). The Vickers hardness showed the maximum hardness value for FCP4 type of composites. The DSC thermo grams illustrated that the increased glass transition temperature (TG) for FCP3 type of composites. The chemical resistant test was showing the excellent results on all types of fly ash and talc dispersed glass fibre reinforced unsaturated polyester composites. The fire performance test was performed by according to UL-94 standard. The fire resistance increases with the increasing of fly ash content. The longest burning time occurs on the composite containing the highest fly ash content (100% of fly ash content).

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2011

B. H. N. Reddy, N Reddy, S., M. Kumar, A., G. Reddy, R., Reddy, G. H., and .V.P.Chakradhar, K., “Mechanical properties of randomly oriented short Sansevieria trifasciata fibre/epoxy composites”, International Journal of Fiber and Textile Research, vol. 1, no. 1, pp. 6–10, 2011.

2010

K. M. Ashok, Reddy, B. H. N., Mohana, R. Y. Venkata, Ramachandra, R. G., Venkatesh, K. N. S., and Nanjunda, R. B. H., “Assement of nanoclay filled epoxy on mechanical, Thermal and chemical resistance properties of nano composites”, Journal of Metallurgy and Materials Science, vol. 52, no. 4, pp. 305-315, 2010.[Abstract]


Clay/epoxy nanocomposites are synthesized by high shear mechanical mixer followed by ultra-sonicator is used to obtain the homogeneous mixture of epoxy and clay under the aid of in-situ polymerization. Compression, impact, hardness, frictional coefficient and chemical resistance properties of the nanocomposites are studied to assess the influence of surface modified clay filled with epoxy as a function of clay. It is observed that all the properties are increased with increasing clay content up to 5 wt. % clay, decreased further increasing in clay content. Mechanical properties are optimally increased at 5 wt. % clay and yet results are compared with neat epoxy matrix. The system is processed by hand-lay up technique for making the test specimens. Fractured surfaces are tested by Scanning Electron Microscope (SEM) unearths reasons for the significant improvements. In Thermogravimetric analysis (TGA), 6°C rise in decomposition temperature is found. Differential scanning calorimetry (DSC) results showed that the modified clay particles affected the glass transition temperature (Tg) of the nanocomposites.

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Publication Type: Conference Proceedings

Year of Publication Title

2017

B. H. N. Reddy and Lakshmi, V. V., “Development of sodium alginate/poly (acrylamide- closite-30B nanoclay) hydrogel composites for paclitaxel anticancer drug transfer applications”, International conference on advances in Science and Engineering (ICASE-2017) on January 20-22, 2017, organized by Regent’s International College, Bangkok, Thailand. 2017.

2016

B. H. N. Reddy and Lakshmi, V. V., “Synthesis and characterization of modified sodium alginate/bentonite clay biocomposite for antimicrobial property”, International Conference on Nano science and Nanotechnology [ICNAN-2016] organized by VIT, Vellore, Coimbatore, India. 2016.

2016

B. H. N. Reddy and V. Lakshmi, V., “Synthesis and characterization of functionalized ZnO nanoparticle in to Na-MMT clay by insitu Sol gel method”, International Conference on Nanotechnology [ICNANO 2016],organized by VTU, Muddenahalli, Chikkaballapur, Bengaluru-562101. 2016.

Publication Type: Conference Paper

Year of Publication Title

2015

B. H. N. Reddy and V. Lakshmi, V., “Preparation of chitosan/different organ modified clay polymer nanocomposites: studies on morphological, swelling, thermal stability and anti-bacterial properties”, in International Conference on “Nano materials and Nanotechnology” organized by Centre for Nan science and Technology, K.S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India, December 7-10, 2015, 2015.

Courses Taught

  • Corrosion science
  • Nanotechnology
  • Environmental science,
  • Fuel cells, Electrochemical energy systems
  • Chemistry of engineering materials
  • Engineering chemistry
  • Chemistry of advanced materials
  • Battery technology
  • Polymers for electronics
  • Material science, etc.