Qualification: 
MSc, BSc
Email: 
damus@am.amrita.edu
Phone: 
+91 8589039320

Damu S completed his Masters in Biotechnology from Amrita School of Biotechnology in 2011.He worked as Guest Lecturer in the Department of Biotechnology at Government College Kariavattom, Thiruvananthapuram,India  during 2011-2012 .

He joined back Amrita School of Biotechnology in 2012 and is currently pursuing his doctoral degree in Biotechnology at Cell Biology Lab with fellowship from Council of Scientific & Industrial Research (CSIR),India.

His current area of interest is in Cancer and Inflammatory Diseases via targeting cyclooxygenase (COX) pathway. More Details »»

 

 

ALMA MATER

  • MSc. Biotechnology, Amrita Vishwa Vidyapeetham (2011)
  • BSc. Biotechnology, Amrita Vishwa Vidyapeetham (2009)

EARLIER AFFILIATION

  • Guest Lecturer in Department of Biotechnology, Government College Kariavattom (2011-2012)
     

AWARDS / HONOR

  • Award of Appreciation from Amrita Vishwa Vidyapeetham,2014
  • Award of Excellence from Amrita Vishwa Vidyapeetham,2012
  • Awarded Council of Scientific & Industrial Research (CSIR)-Junior Research Fellowship, India ,2012
  • Awarded CSIR-UGC-NET for Lectureship, 2011
  • Qualified  Graduate Aptitude Test in Engineering (GATE) , 2011

 

Research experience

  1. The Project entitled “Modulatory Effect of Curcumin in Hypobaric Hypoxia Induced Pulmonary Edema - A Molecular Approach ” has been carried out at Defence Insitute of Physiology and Allied Science(DIPAS), Lucknow Road, Timarpur, Delhi under the guidance of Dr.S Sarada Suryakumari
  2. The project entitled “Antimicrobial activity of different allopathic, homeopathic and ayurvedic medicines against Klebsiella pneumoniae” was carried under the guidance of Ms. Athira O , Amrita School of Biotechnology, Amritapuri, Kollam

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

D. Sunilkumar, Bose, C., Shaji, S. K., Pandurangan, N., Kumar, G. B., Banerji, A., and Dr. Bipin G. Nair, “Coconut Shell Derived Bioactive Compound Oxyresveratrol Mediates Regulation Of Matrix Metalloproteinase 9”, International Journal of Pharma and Bio Sciences, vol. 8, no. 1, pp. 202 – 210, 2017.

2014

Journal Article

K. Amrutha, Nanjan, P., Shaji, S. K., Sunilkumar, D., Subhalakshmi, K., Rajakrishna, L., and Banerji, A., “Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells—A SAR study”, Bioorganic & medicinal chemistry letters, vol. 24, no. 19, pp. 4735–4742, 2014.[Abstract]


Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-κB (NF-κB) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-κB activation. The modulation of expression of two NF-κB regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-κB, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3′-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure–activity relations amongst the flavonoids as NF-κB signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-κB activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols.

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Faculty Research Interest: 
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