Qualification: 
MSc, BSc
Email: 
meeravenugopal@am.amrita.edu
Phone: 
+918589064123

Meera Venugopal is currently a Research Scholar at the School of Biotechnology. She received his masters in Biotechnology from Amrita Vishwa Vidyapeetham, Amritapuri in 2012. She is currently pursuing her PhD in Biotechnology at Cell Biology Lab.

ALMA MATER

  • M. Sc. Biotechnology, Amrita Vishwa Vidyapeetham (2012)
  • B. Sc. Microbiology, Amrita Vishwa Vidyapeetham (2010)
     

AWARDS / HONOURS

  • Qualified CSIR-UGC-NET for Lectureship, 2011
  • Qualified GATE exam, 2012
  • 1st rank in B. Sc. Microbiology (2007-2010) from Amrita Vishwa Vidyapeetham

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2016

Journal Article

Dr. Jyotsna Nambiar, Bose, C., Meera Venugopal, Dr. Asoke Banerji, Patel, T. B., Dr. Geetha Kumar, and Dr. Bipin G. Nair, “Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK”, Experimental Cell Research, vol. 349, pp. 139-151, 2016.[Abstract]


Earlier studies from our laboratory have identified Anacardic acid (AA) as a potent inhibitor of gelatinases (MMP-2 and 9), which are over-expressed in a wide variety of cancers (Omanakuttan et al., 2012). Disruption of the finely tuned matrix metalloproteinase (MMP) activator/inhibitor balance plays a decisive role in determining the fate of the cell. The present study demonstrates for the first time, that in addition to regulating the expression as well as activity of gelatinases, AA also inhibits the expression of its endogenous activators like MMP-14 and Extracellular Matrix MetalloProteinase Inducer (EMMPRIN) and induces the expression of its endogenous inhibitor, REversion-inducing Cysteine-rich protein with Kazal motifs (RECK). In addition to modulating gelatinases, AA also inhibits the expression of various components of the Epidermal Growth Factor (EGF) pathway like EGF, Protein Kinase B (Akt) and Mitogen-activated protein kinases (MAPK). Furthermore, AA also activates the expression of Sprouty 2 (Spry2), a negative regulator of EGF pathway, and silencing Spry2 results in up-regulation of expression of gelatinases as well as MMP-14. The present study thus elucidates a novel mechanism of action of AA and provides a strong basis for utilizing this molecule as a template for cancer therapeutics.

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PDF iconanacardic-acid-inhibits-gelatinases-through-the-regulation-of-spry-2-mmp-14-emmprin-and-reck-11october2016.pdf

Publication Type: Conference Paper

Year of Publication Publication Type Title

2012

Conference Paper

A. Krishnan, Shyam, J., Meera Venugopal, and Vijayakumar, V., “A single phase inverter based system to utilize distributed sources for storage and grid integration”, in 2012 IEEE Conference on Sustainable Utilization and Development in Engineering and Technology, STUDENT 2012 - Conference Booklet, Kuala Lumpur, 2012, pp. 57-62.[Abstract]


There is tremendous pressure on power systems all over the world to cater to an increasing demand for power. One of the measures which have been suggested to alleviate this problem to a certain extent is distributed generation. This could improve quality of supply in rural areas as well as connect several unconnected villages to the grid. This paper details the development of a model distributed generation system comprising of a solar and wind source. The system incorporates storage of energy as well as injection of energy into the grid. © 2012 IEEE.

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