Qualification: 
MSc, BSc
meghaprasad@am.amrita.edu
Phone: 
+91 476 2805316

Megha currently serves as Junior Research Fellow at Amrita School of Biotechnology after completing her Masters in Biotechnology from Amrita School of Biotechnology in 2014. She is pursuing her doctoral degree in Biotechnology at Sanitation Biotechnology lab, Amrita School of Biotechnology under the guidance of Dr. Sanjay Pal.

ALMA MATER

  • MSc Biotechnology, Amrita School of Biotechnology (2014)
  • BSc Biotechnology, Amrita School of Biotechnology (2012)
     

AWARDS / HONOR

  • Awarded with Junior Research Fellowship from Amrita Vishwa Vidyapeetham.
  • Secured 50th rank in National Eligibility Test (NET) - Lectureship, December 2013 conducted by Council of Scientific & Industrial Research (CSIR), India –University Grant Commission (UGC), India.
     

RESEARCH EXPERIENCE

  • The project entitled In Vitro Profiling Of Natural Compounds- P-X1, P-X2 And P-X3” was carried out under the guidance of Dr. Srinivas Boreddy, Senior Scientist, Piramal Life Sciences, Mumbai.
  • Worked on Microbial Fuel Cell under the guidance of Mr. Ajith Madhavan in the Green Energy Lab at Amrita School of Biotechnology.
     

ONGOING RESEARCH PROJECT

Lytic agents against enteric parasite for sanitation

Publications

Publication Type: Journal Article

Year of Publication Title

2020

A. Vijayakumar, Madhavan*, A., Chinchu Bose, Pandurangan Nanjan, Kokkal, S. S., Veedu, A. P., Megha Prasad, Dr. Sanjay Pal, and Dr. Bipin G. Nair, “Potent Chitin Synthase Inhibitors from Plants”, Current Bioactive Compounds, vol. 16, no. 1, 2020.[Abstract]


Background: Chitin is the main component of fungal, protozoan and helminth cell wall. Theyhelp to maintain the structural and functional characteristics of these organisms. The chitin wall is dynamicand is repaired, rearranged and synthesized as the cells develop. Active synthesis can be noticedduring cytokinesis, laying of primary septum, maintenance of lateral cell wall integrity and hyphal tipgrowth. Chitin synthesis involves coordinated action of two enzymes namely, chitin synthase (that laysnew cell wall) and chitinase (that removes the older ones). Since chitin synthase is conserved in differenteukaryotic microorganisms that can be a ‘soft target’ for inhibition with small molecules. Whenchitin synthase is inhibited, it leads to the loss of viability of cells owing to the self- disruption of thecell wall by existing chitinase.Methods: In the described study, small molecules from plant sources were screened for their ability tointerfere with hyphal tip growth, by employing Hyphal Tip Burst assay (HTB). Aspergillus niger wasused as the model organism. The specific role of these small molecules in interfering with chitin synthesiswas established with an in-vitro method. The enzyme required was isolated from Aspergillus nigerand its activity was deduced through a novel method involving non-radioactively labelled substrate. Theactivity of the potential lead molecules were also checked against Candida albicans and Caenorhabditiselegans. The latter was adopted as a surrogate for the pathogenic helminths as it shares similarity withregard to cell wall structure and biochemistry. Moreover, it is widely studied and the methodologies arewell established.Results: Out of the 11 compounds and extracts screened, 8 were found to be prospective. They werealso found to be effective against Candida albicans and Caenorhabditis elegans.Conclusion: Purified Methyl Ethyl Ketone (MEK) Fraction1 (F1) of Coconut (Cocos nucifera) ShellExtract (COSE) was found to be more effective against Candida albicans with an IC50 value of 3.04μg/mL and on L4 stage of Caenorhabditis elegans with an IC50 of 77.8 μg/mL.

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2019

Pradeesh Babu, Veedu, A. Palillam, Vidhya Prakash, Megha Prasad, Amrita Salim, Ajith Madhavan, Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Draft Genome Sequence of a Lactobacillus fermentum Strain Isolated from Domestic Sewage in Kerala, India”, Microbiology Resource Announcements, vol. 9, 2019.[Abstract]


We report the draft genome sequence of a putative probiotic strain, Lactobacillus fermentum ASBT-2, isolated from domestic sewage in Kerala, India. The strain showed probiotic properties (tolerance to low pH and bile salts, binding to host matrix) and reduced the coliform count by 90% in a biofilter used to treat wastewater.

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2018

A. Vijayakumar, Ajith Madhavan, Chinchu Bose, Nanjan Pandurangan, Sindhu Shetty K., Archana Palillamvedu, Megha Prasad, Dr. Sanjay Pal, and Dr. Bipin G. Nair, “Potent Chitin Synthase Inhibitors from Plants”, Current Bioactive Compounds, vol. 14, 2018.

Publication Type: Conference Paper

Year of Publication Title

2018

V. Amrutha., Megha Prasad, A. Lekshmija, R Anjana, S. Aleena, Dr. Bipin G. Nair, Ajith Madhavan, and Dr. Sanjay Pal, “Effect of compost derived lytic agents against enteric bacteria in sewage”, in InnovativeStrategies for Sustainable Water Management (ISSWM-2017), Punjab, India. , 2018.

2017

Ajith Madhavan, Megha Prasad, S. Girish, Sindhu Shetty K., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Caulobacter crescentus as a novel exoelectricigen in a dual chambered Microbial Fuel Cell (MFC)”, in Technical Program Committee of the “2017 IEEE International( Biennial) Conference on Technological Advancements in Power and Energy”, TAP Energy-2017. , 2017.

2015

Megha Prasad, “Caulobacter crescentus as a novel exoelectricigen in a dual chambered Microbial Fuel Cell (MFC)”, in 56th Annual Conference of Association of Microbiologists of India and International Symposium on “Emerging Discoveries in Micrbiology(Poster), JNU, Delhi, 2015.

Publication Type: Conference Proceedings

Year of Publication Title

2017

Divya Nedungadi, Megha Prasad, Anupama Binoy, Patra, G., Silva, J. D., Chatterjee, M., Jacob, A., Babu, A. S., Alexin, R., Dr. Bipin G. Nair, Dr. Sanjay Pal, and Dr. Nandita Mishra, “Anthelmintic properties of ginger compounds”, 27th Swadeshi Science Congress, November 7-9, 2017. Kerala, India, 2017.

Faculty Research Interest: