During the course of our work on the synthesis of bioactive compounds, new low-valent titanium (LVT)- mediated reactions were discovered. These include: i) a short synthesis of oxygen heterocycles via intramolecular reductive deoxygenation between ketone and ester functions in aromatic systems, ii) an unusual ortho-hydroxyl-assisted reduction/isomerisation of aromatic alkenes, iii) reductive dealkoxylation of aryl alkyl ethers, iv) one-pot synthesis of polycyclic aromatic hydrocarbons from o-alkoxy aromatic aldehydes/ketones involving reductive deoxygenation, reductive dealkoxylation and intramolecular C-C coupling in tandem, v) a novel approach to the deprotection of allyl, propargyl and benzyl ethers of alcohols and phenols and N-benzyl/allyl amines, and vi) modulation of the activity of LVT reagent by nitrogen heterocycles. Mechanism and synthetic implications of these reactions are discussed.
S. K. Nayak, Kadam, S. M., Talukdar, S., and Banerji, A., “Low-valent titanium: New synthetic applications (Invited contribution)”, Journal of the Indian Institute of Science, vol. 74, pp. 401-410, 1994.