Publication Type : Journal Article
Publisher : International Journal of Chemical Science
Source : International Journal of Chemical Science, vol. 7, pp. 1905-1910, 2017.
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis
Year : 2017
Abstract : Typha angustifolia of the family typhaceae is commonly known as elephant grass. It is mainly
used in folk remedies for the treatment of tumours, as anticoagulant, astringent, sedative and tonics. The
present study was to isolate and characterise phytochemical constituents and to find out the
anti-microbial activity of the extract and isolated compounds of Typha angustifolia. The powdered
material was defatted with petroleum ether followed by the extraction of mark by using Soxhlet
extraction process. The extract was dried and concentrated and was used for further investigation. Dried
extract showed the presence of alkaloids, sterols and flavanoids. Then the extract was subjected to
isolation of chemical substance by column chromatography. Two compounds were isolated from
methanolic extract and these were characterised by IR, MS and spectro polarimeter. The characterisation
report showed the presence of nonacosanol and lupeol acetate. The methanolic extracts and the isolated
compounds were subjected to the antimicrobial activity against both bacteria and fungi like Aspergillus
flavus, Serratia, E. coli, Listeria and Staphylococcus aureus by disc diffusion method. It was compared
with standard drug (ciprofloxacin, griseofulvin). Methanolic extract and isolated compounds were found
to possess potent antibacterial and antifungal activity.
Cite this Research Publication : Dr. S. Sathianarayanan, Varghese, A., Gavani, U., Abraham, S., and Parambi, D. Grace Thom, “Phytochemical Screening and Antimicrobial investigation of Typha angustifolia linn.”, International Journal of Chemical Science, vol. 7, pp. 1905-1910, 2017.