Publication Type:

Journal Article

Source:

Proteomics, Volume 11, Number 4, p.620-630 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79551475673&partnerID=40&md5=7e50ff0d4de60c16be319d5249a0f750

Keywords:

alanylaspartylisoleucylglycylisoleucylalanylmethionylglycylserylglycylthreonylglutamylvalylalanyllysine, amino acid sequence, Animals, aspartylprolylprolylaspartylprolylhistidylglutaminylprolylaspartylmethionylthreonyllysine, bacterial gene, biological marker, Biological Markers, Chromosome Mapping, DNA sequence, fungal gene, genetic variability, genomics, Harness, Humans, liquid chromatography mass spectrometry, mass spectrometry, Mice, nonhuman, nucleotide sequence, peptide, priority journal, protein analysis, Proteins, proteogenomics, proteomics, review, serylserylalanylglutaminylaspartylasparaginylmethionylvalylglutaminylhistidylasparaginylasparaginylthreonyllysine, single nucleotide polymorphism, Software, Systems Biology, tryptophylglycylphenylalanylglycylaspartylleucylalanylvalylcysteinylaspartylglycylglutamyllysine, unclassified drug, valylglycylleucylglutamylglycylglutamylglutamylaspartyllysine

Abstract:

The ability to sequence DNA rapidly, inexpensively and in a high-throughput fashion provides a unique opportunity to sequence whole genomes of a large number of species. The cataloging of protein-coding genes from these species, however, remains a non-trivial task with the majority of initial genome annotation dependent on the use of gene prediction algorithms. Recent advances in mass spectrometry-based proteomics now enable generation of accurate and comprehensive protein sequence of tissues and organisms. Proteogenomics allows us to harness the wealth of information available at the proteome level and apply it to the available genomic information of organisms. This includes identifying novel genes and splice isoforms, assigning correct start sites and validating predicted exons and genes. It is also possible to use proteogenomics to identify protein variants that could cause diseases, to identify protein biomarkers and to study genome variation. We anticipate proteogenomics to become a powerful approach that will be routinely employed by 'Genome and Proteome Centers' of the future. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Notes:

cited By (since 1996)26

Cite this Research Publication

Sab c Renuse, Chaerkady, Rac, and Pandey, Acd e, “Proteogenomics”, Proteomics, vol. 11, pp. 620-630, 2011.