Dr. Vindhya Savithri joined the Department of Oral & Maxillofacial Pathology and Microbiology at Amrita in September 2010.

She completed her B. D. S. and M. D. S. degrees from Government Dental College, Calicut. Before joining Amrita, she worked at Annoor Dental College, Muvattupuzha during October 2005 to September 2010. She has over 7 years of combined work experience in clinics, research and academia.

She has both presented and published papers in national forums.


Publication Type: Journal Article

Year of Publication Title


M. Janardhanan, Suresh, R., Savithri, V., and Veeraraghavan, R., “Extranodal Diffuse Large B Cell Lymphoma of Maxillary Sinus Presenting as a Palatal Ulcer”, BMJ Case Rep, vol. 12, no. 2, 2019.[Abstract]

A multitude of disease processes ranging from periodontitis to malignancies can lead to formation of solitary ulcer on the palate. Hence solitary ulcers of palate can often be a challenging one to diagnose. We report an interesting case of a diffuse large B cell lymphoma of the maxillary sinus which perforated the palatal bone and presented clinically as a palatal ulcer. Initially the lesion manifested as a small ill-defined swelling in the posterior palatal slope in relation to 24and25 which were mobile and hence was erroneously diagnosed as chronic periodontal abscess. This paper is intended to stress the relevance of including non-Hodgkin's lymphoma in the differential diagnosis of solitary palatal ulcers as it may be often misdiagnosed as more common reactive or inflammatory lesions.

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A. Aiswarya, Suresh, R., Janardhanan, M., Savithri, V., Aravind, T., and Mathew, L., “An Immunohistochemical Evaluation of Podoplanin Expression in Oral Leukoplakia and Oral Squamous Cell Carcinoma to Explore its Potential to be used as a Predictor for Malignant Transformation.”, J Oral Maxillofac Pathol, vol. 23, no. 1, p. 159, 2019.[Abstract]

<p><b>Background: </b>Oral leukoplakia (OL) is a potentially malignant disorder with increased risk for the development of oral squamous cell carcinoma (OSCC). Many cases of OSCC arise from the malignant transformation of preexisting OL. However, the risk of progression into OSCC and the possible prediction of malignant potential of OL remain inconclusive. Recent studies have shown that podoplanin, a mucin-like transmembrane glycoprotein specifically expressed in lymphatic endothelial cells, is expressed in various neoplasms including OSCC, indicating its possible biologic role in tumor cells. In this study, an evaluation of podoplanin expression in OL and OSCC has been carried out to assess its potential role as a biomarker to predict the possibility of malignant transformation in OL cases.</p>

<p><b>Aims and Objectives: </b>To assess the usefulness of podoplanin as a potential biomarker for predicting the risk of malignant transformation in OL, by comparing its immunohistochemical expression in OL and OSCC.</p>

<p><b>Materials and Methods: </b>Archival paraffin-embedded blocks of 25 OL cases with varying grades of dysplasia and 30 OSCC cases showing its varying grades were selected. Sections were subjected to immunohistochemical staining for podoplanin and compared with the control group for evaluation of results in the three groups.</p>

<p><b>Results: </b>A statistically significant increase in podoplanin expression was observed from normal mucosa through OL to OSCC. In the OL cases, the podoplanin staining score progressively increased from mild dysplasia to carcinoma , whereas in OSCC, well-differentiated group showed the maximum expression of podoplanin.</p>

<p><b>Conclusion: </b>The progressive increase in podoplanin expression through the increasing grades of dysplasia in OL is suggestive of an increased risk for malignant transformation with increased expression of podoplanin in OL cases. A high podoplanin expression in the well-differentiated OSCC may indicate a vital role for podoplanin in the early stages of tumorigenesis.</p>

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M. Janardhanan, Dr. Rakesh S., Savithri, V., and Thara Aravind, “Peripheral Ameloblastoma with Neoplastic Osseous Invasion Versus Peripheral Intraosseous Ameloblastoma: A Challenging Diagnosis”, J Oral Maxillofac Pathol, vol. 22, no. 3, pp. 396-400, 2018.[Abstract]

Peripheral ameloblastoma, a soft-tissue analogue of intraosseous ameloblastoma, is a rare odontogenic tumor with histologic characteristics of ameloblastoma. In contrast to conventional ameloblastoma, peripheral ameloblastomas are considered as innocuous lesions which usually do not show invasion of the underlying structures. Rarely, intraosseous ameloblastoma which penetrates the alveolar bone can fuse with the overlying oral epithelium and eventually manifest as an exophytic peripheral lesion. Such lesions which mimic peripheral ameloblastoma both clinically and microscopically are termed as peripheral intraosseous ameloblastoma. As per the existing criteria, soft-tissue ameloblastomas showing bone invasion are strictly excluded from the category of peripheral ameloblastoma and are considered as peripheral intraosseous ameloblastoma. We report a rare case of extraosseous ameloblastoma with clear origin from the superficial epithelium showing the presence of a few odontogenic islands in the underlying bone suggestive of a neoplastic osseous invasion. This paper discusses the diagnostic challenges associated with peripherally occurring ameloblastomas and stresses the need for accurate diagnosis in deciding the treatment modalities

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V. Savithri, Dr. Rakesh S., Janardhanan, M., and Thara Aravind, “Metastatic Adenocarcinoma of Mandible: in Search of the Primary”, BMJ Case Rep, vol. 11, no. 1, 2018.[Abstract]

We present here a case of a 64-year-old female patient who reported with a complaint of pain in the chin region of 3-month duration. The radiographs revealed an irregular radiolucent lesion in the anterior part of the mandible. An incisional biopsy was carried out and the microscopy showed features of adenocarcinoma. Suspecting a metastatic lesion, the patient was then sent for whole body examination which showed a mass in the lungs. A whole body scan also showed metastasis to other organs such as kidney, gallbladder and vertebrae. This case is unusual in that the patient complained only of a vague jaw pain with no other systemic symptoms even in the presence of widespread disease.

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T. Aravind, Janardhanan, M., Dr. Rakesh S., Savithri, V., and Unnikrishnan, U. G., “Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium”, Journal of Oral and Maxillofacial Pathology, vol. 21, pp. 18-23, 2017.[Abstract]

Background: Early detection of oral squamous cell carcinoma (OSCC) remains one of the most efficient ways to ensure patient survival and improved quality of life. Although specific biomarkers related to OSCC have been investigated, a useful biomarker that assesses the transition potential of potentially malignant lesion to OSCC remains to be found. Osteopontin (OPN) has been recognized as an important factor in tumorigenesis and their expression in OSCC have been investigated earlier. In the present study, evaluation of OPN expression in premalignant and malignant lesions has been carried out to assess their possible role as a biomarker in the early diagnosis and prognosis of OSCC. Objectives: The objective of this study is to evaluate the role of OPN as a biomarker in the diagnosis and prognosis of OSCC. Materials and Methods: The study group consisted of archival paraffin-embedded blocks of ten cases each of varying grades of OSCC, oral epithelial dysplasias and epithelial hyperplasias. Sections were subjected to immunohistochemical staining for the biomarker OPN. Results: A positive OPN expression was noticed in epithelial dysplasias and SCC arising from the oral epithelium. A progressive increase in the intensity of staining was seen with increasing grades of dysplasias and a decrease in OPN expression with an increase in grades was observed in OSCC. Conclusion: The expression of OPN in full thickness of epithelium in severe dysplasias, carcinoma in situ, and in the superficial epithelium of OSCC suggest the possibility of considering OPN expression in full epithelial thickness in dysplasias as an indicator for malignant transformation. © 2017 Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow.

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M. Janardhanan, Rakesh, S., and Savithri, V., “Oral dirofilariasis”, Indian journal of dental research : official publication of Indian Society for Dental Research, vol. 25, pp. 236-239, 2014.[Abstract]

Filariasis affecting animals can rarely cause infections in human beings through the accidental bite of potential vectors. The resulting infection in man, known as zoonotic filariasis occur worldwide. Human dirofilariasis, the most common zoonotic filariasis, is caused by the filarial worm belonging to the genus Dirofilaria. Dirofilarial worms, which are recognized as pathogenic in man can cause nodular lesions in the lung, subcutaneous tissue, peritoneal cavity or eyes. Oral dirofilariasis is extremely rare and only a few cases have been documented. We report an interesting case of dirofilariasis due to Dirofilaria repens involving buccal mucosa in a patient who presented with a facial swelling. The clinical features, diagnostic issues and treatment aspects are discussed. This paper stresses the importance of considering dirofilariasis as differential diagnosis for subcutaneous swelling of the face, especially in areas where it is endemic.

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V. Savithri, Janardhanan, M., Dr. Rakesh S., and Kumar, R., “Desmoplastic ameloblastoma with osteoplasia: Review of literature with a case report”, Journal of Oral and Maxillofacial Pathology, vol. 17, pp. 298-301, 2013.[Abstract]

Desmoplastic ameloblastoma (DA) is a relatively rare histological variant of ameloblastoma with specific clinical, radiological, and histological features. This tumor is more commonly seen in the anterior region of jaws as a mixed radiopaque-radiolucent lesion resembling benign fibro-osseous lesions. Histologically, DA is characterized by small nests and strands of «compressed» odontogenic epithelium supported by pronounced collagenized stroma. Metaplastic bone formation has been reported in few cases. This report describes a lesion in the left anterior maxilla of a young female patient.

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