Dr. Vindhya Savithri joined the Department of Oral & Maxillofacial Pathology and Microbiology at Amrita in September 2010.

She completed her B. D. S. and M. D. S. degrees from Government Dental College, Calicut. Before joining Amrita, she worked at Annoor Dental College, Muvattupuzha during October 2005 to September 2010. She has over 7 years of combined work experience in clinics, research and academia.

She has both presented and published papers in national forums.


Publication Type: Journal Article

Year of Publication Title


T. Aravind, Janardhanan, M., Dr. Rakesh S., Savithri, V., and Unnikrishnan, U. G., “Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium”, Journal of Oral and Maxillofacial Pathology, vol. 21, pp. 18-23, 2017.[Abstract]

Background: Early detection of oral squamous cell carcinoma (OSCC) remains one of the most efficient ways to ensure patient survival and improved quality of life. Although specific biomarkers related to OSCC have been investigated, a useful biomarker that assesses the transition potential of potentially malignant lesion to OSCC remains to be found. Osteopontin (OPN) has been recognized as an important factor in tumorigenesis and their expression in OSCC have been investigated earlier. In the present study, evaluation of OPN expression in premalignant and malignant lesions has been carried out to assess their possible role as a biomarker in the early diagnosis and prognosis of OSCC. Objectives: The objective of this study is to evaluate the role of OPN as a biomarker in the diagnosis and prognosis of OSCC. Materials and Methods: The study group consisted of archival paraffin-embedded blocks of ten cases each of varying grades of OSCC, oral epithelial dysplasias and epithelial hyperplasias. Sections were subjected to immunohistochemical staining for the biomarker OPN. Results: A positive OPN expression was noticed in epithelial dysplasias and SCC arising from the oral epithelium. A progressive increase in the intensity of staining was seen with increasing grades of dysplasias and a decrease in OPN expression with an increase in grades was observed in OSCC. Conclusion: The expression of OPN in full thickness of epithelium in severe dysplasias, carcinoma in situ, and in the superficial epithelium of OSCC suggest the possibility of considering OPN expression in full epithelial thickness in dysplasias as an indicator for malignant transformation. © 2017 Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow.

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M. Janardhanan, Rakesh, S., and Savithri, V., “Oral dirofilariasis”, Indian journal of dental research : official publication of Indian Society for Dental Research, vol. 25, pp. 236-239, 2014.[Abstract]

Filariasis affecting animals can rarely cause infections in human beings through the accidental bite of potential vectors. The resulting infection in man, known as zoonotic filariasis occur worldwide. Human dirofilariasis, the most common zoonotic filariasis, is caused by the filarial worm belonging to the genus Dirofilaria. Dirofilarial worms, which are recognized as pathogenic in man can cause nodular lesions in the lung, subcutaneous tissue, peritoneal cavity or eyes. Oral dirofilariasis is extremely rare and only a few cases have been documented. We report an interesting case of dirofilariasis due to Dirofilaria repens involving buccal mucosa in a patient who presented with a facial swelling. The clinical features, diagnostic issues and treatment aspects are discussed. This paper stresses the importance of considering dirofilariasis as differential diagnosis for subcutaneous swelling of the face, especially in areas where it is endemic.

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V. Savithri, Janardhanan, M., Dr. Rakesh S., and Kumar, R., “Desmoplastic ameloblastoma with osteoplasia: Review of literature with a case report”, Journal of Oral and Maxillofacial Pathology, vol. 17, pp. 298-301, 2013.[Abstract]

Desmoplastic ameloblastoma (DA) is a relatively rare histological variant of ameloblastoma with specific clinical, radiological, and histological features. This tumor is more commonly seen in the anterior region of jaws as a mixed radiopaque-radiolucent lesion resembling benign fibro-osseous lesions. Histologically, DA is characterized by small nests and strands of «compressed» odontogenic epithelium supported by pronounced collagenized stroma. Metaplastic bone formation has been reported in few cases. This report describes a lesion in the left anterior maxilla of a young female patient.

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PDF icon Desmoplastic-Ameloblastoma-with-Osteoplasia-Review-of-Literature-With-a-Case-Report.pdf

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