The Discovery of MicroRNAs (miRNAs) that Regulate the Expression of Gelatinase A (Matrix metalloproteinase-2/MMP-2) and B (Matrix metalloproteinase-9/MMP-9) in Colon Cancer Cells

MicroRNAs (miRNAs) are short double stranded RNAs that are produced endogenously in mammalian cells, and control the regulation of many target genes at the post-transcriptional level. There are many reports of the misregulation of these miRNAs in cancer. We will be studying the regulation of MMP-2 & MMP-9 by miRNAs, and the effect of natural products on the modulation of these miRNAs.