Back close

Role of Staphylococcal Pathogen Associated Molecular Patterns in Septic Arthritis

Start Date: Sunday, Jul 01,2012

School: School of Nano Sciences

Project Incharge:Dr. Lalitha Biswas
Funded by:DST (SERB)
Role of Staphylococcal Pathogen Associated Molecular Patterns in Septic Arthritis

Staphylococcus aureus is the commonly found bacteria in septic arthritis. Methicillin resistant S.aureus (MRSA) is the most common cause of community-onset adult septic arthritis. It has been documented that S.aureus cell surface associated components can induce sepsis, organ injury, and septic arthritis. 

S.aureus mutants that are defective in production of particular cell wall components like O-aetylation of peptidoglycan, wall teichoic acids, surface proteins, lipoproteins and lipoteichoic acids have been generated.

The team would like to validate the role of these cell wall components (rigidity, cross-linking and solubility of the peptidoglycan, presence of peptidoglycan linked surface proteins, wall teichoic acids, lipoteichoic acids and lipoproteins, etc.) in causing septic arthritis in mice model.

The aim of this project will be to validate and identify the following:

  • To identify the common Staphylococcal PAMPs, which induce septic arthritis.
  • To identify Staphylococcal mutants that can activate least production of inflammatory cytokines including tumor necrosis factor alpha (TNF-α), IL-6, IL-8 and granulocytemacrophage colony-stimulating factor and IL-1α.
  • Once the most potent PAMP is identified, the aim is to generate and validate the purified antibody against this particular PAMP which could play a role in the prevention of septic arthritis.

Related Projects

Identification and Functional Analysis of Probiotic Bacterial Surface Associated Proteins in Preventing Enteropathogenic Infections
Identification and Functional Analysis of Probiotic Bacterial Surface Associated Proteins in Preventing Enteropathogenic Infections
Combining Solar Cells with Supercapacitors and Batteries Integrated Nanomaterial based Photovoltaic Storage Devices
Combining Solar Cells with Supercapacitors and Batteries Integrated Nanomaterial based Photovoltaic Storage Devices
Preparation of Carboxymethyl Chitin and Chitosan Derivatives
Preparation of Carboxymethyl Chitin and Chitosan Derivatives
Electro Nanoprocessing of Semiconductor Nanotube Arrays for High Efficiency Photovoltaics
Electro Nanoprocessing of Semiconductor Nanotube Arrays for High Efficiency Photovoltaics
Novel Target-Specific Multiplexed Nano- Phytomedicines for Cancer Therapy
Novel Target-Specific Multiplexed Nano- Phytomedicines for Cancer Therapy
Admissions Apply Now