[DBT] Design and Validation of Point of Care Disposable Sensor Strips for Diagnosis of Tuberculosis from Urine Samples

Tuberculosis (TB) is believed to affect nearly one third of the world population with approximately 9 million new cases detected every year. Current methods of diagnosis includes sputum smear microscopy, chest X-Ray and biopsy which are time consuming and expensive with a low level of accuracy. By developing a disposable strip and a meter for the early detection of tuberculosis, affordable and point-of-care diagnosis can be realized.

Principle Investigator: Dr. Urvashi B. Singh, AIIMS, Delhi
Co-Investigator:: Dr. T. G. Satheesh Babu , Dr. John Stanley

[DBT] Affordable paper based microfluidics point of care testing device for liver function

It is seen that therapies for diabetes and heart disease affects liver and these diseases are increasing in prevalence especially in developing countries. By using paper as a platform for the liver tests, affordable point-of-care devices can be realized. Also, paper offers many advantages like low cost, minimal requirement of sample, abundant, specific, and has excellent reproducibility and sensitivity.

Principle Investigator: Dr. T. G. Satheesh Babu
Co-Investigator:: Dr. Bipin Nair , Dr. T. Ramachandran

[DBT] Cost effective device and cloud enabled smart solution for diabetes care

The joint effort by Amrita and Wipro has the goal of making diabetes care available, accessible and affordable for the Indian masses. Amrita and Wipro has envisaged a patient-centric solution wherein low cost diabetes care devices (glucose strips, glucometers & insulin pumps) will interact with users through mobile applications using the cloud gateway. Innovative features of the device will make diabetes management easier for Indian patients and physicians. While Amrita Institute has in-house capabilities of making innovative low-cost diabetes-care product prototypes, it understandably does not have expertise in incorporating these devices into an integrated infrastructure where the devices can act as touch points between the patient and the healthcare provider through smart interfaces. With a proven track record in fields like remote patient monitoring and cloud & mobile connectivity, Wipro has the perfect complementary expertise in making cloud gateway and infrastructure, device-to-application data transfer and interactive platforms. Thus the synergy between Amrita and Wipro promises to leverage their individual strengths and provide an integrated diabetes care solution.

Principle Investigator: Dr. Bipin Nair
Co-Investigator: Dr. T. G. Satheesh Babu

[DBT] Development of lab-on-a-chip for the early detection of cancer in women

A method that is specific and reliable for detecting cancers at early stages and of at an affordable cost which can function as a first-line guidance is of utmost importance. Sensor technology has provided a promising future for the detection of many important diseases through rapid, sensitive and easy applications. Getting high specific and sensitive results by this technology for the detection of biomarkers from blood samples may provide both early and easy detection of cancer without pain with a minimally-invasive technique. Due to the high prevalence of breast, cervical and ovarian cancer in Indian women our aim is to develop a device that can detect cancer at an early stage. A lab-on-a-chip device, which integrates sensors that can detect the above mentioned cancers, will be highly pragmatic due to portability, simplicity of use and affordability. Further this proposed technology can be employed for the mass population screening.

Principle Investigator: Dr. T. G. Satheesh Babu

[DBT] Lab-on-a-chip (LOC) for the Monitoring of Diabetes, Cholesterol and Kidney Function

The proposed work envisages the fabrication of microfluidic lab-on-a-chip (LOC) module for non-enzymatic sensing of glucose, cholesterol and creatinine using a single device. This consists of a disposable LOC and a non disposable electronics module. The use of non-enzymatic sensing module helps to achieve longer shelf life, eliminating the need for stringent storage conditions. This reduces the cost and time of analysis considerably. The point of care diagnostic device provides an effective alternative for the existing expensive and time consuming clinical analysis performed by a trained clinical lab technician. This would thereby enable access to low-cost medical diagnostics even to underprivileged sections of the society.

Principle Investigator: Dr. Bipin Nair
Co-Investigator: Dr. T. G. Satheesh Babu, Dr. T. Ramachandran, Mr. K. Guruvayurappan

[DBT] Development and Fabrication of non-enzymatic Electrochemical Glucose Biosensor and Fabrication of Glucometer

Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has serious drawbacks like insufficient long-term stability, which originates from the intrinsic nature of the enzymes. This project aims at development and fabrication of non-enzymatic glucose sensor and a glucometer. Electrode surface modified with nanomaterials such as carbon nanotubes and transition metal nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. Sensors and biosensors modified with metal nanoparticles reveal good performances such as increased mass transport, catalysis, good biocompatibility and control over the electrode microenvironment when compared with macroelectrodes. Therefore, their use is an important strategy in the construction of non-enzymatic glucose sensors.

Principle Investigator: Dr. T.G.Satheesh Babu
Co-Investigator: Dr. Bipin Nair, Dr. T. Ramachandran

[ISRO Bangalore] Electrodeposition of Aluminium-Lithium alloys for cryo and space applications

The objective of the work is to make aluminum alloys containing lithium, copper, and zirconium for aerospace applications. Moderately thick deposits of binary and ternary alloys of aluminum with lithium, copper and zirconium were successfully electrodeposited. This was achieved from a low cost room temperature ionic liquid containing AlCl3 and triethylammine hydrochloride (Et3NHCl). Electroforming of these alloys was performed on plastic substrates for real-time applications. The highly corrosion resistant coatings obtained are extremely important in aerospace and marine applications. The deposited alloys were thoroughly analyzed for its morphology and crystalline and are found to be highly uniform and crystalline.

Principle Investigator: Dr. T. G. Satheesh Babu
Co-Investigator: Dr. T. Ramachandran, Dr. M. Sivadayanidhi

[DST-TIFAC CORE] Development of amperometric glucose biosensors (as a part of DST-TIFAC CORE in Biomedical technology)

The aim of the project is develop a glucose sensor which work in closed-loop with the insulin pump.

Synthesis of Lube/fuel additive from CNSL - UTeC Corporation, Colorado, USA

Oil soluble alkyl substituted hydroxy aromatic compounds functionalized with amine or substituted amines are commonly used as additives in lube oil and fuel oil, since these compounds have potential activity as oxidation inhibitor (antioxidant), emulsifier and crank case detergent. Mannich base derivatives of polyisobutenylsucinicanhydride are the most common. Cardanol which is obtained by the distillation (decarboxylation) of cashew nut shell liquid is chemically an alkyl substituted phenol. It is used in all kinds of industries right from polymer to medicine. The greatest advantage with cardanol is that it is available from renewable source and it is biodegradable and eco-friendly. The objective of the project is to synthesize long chain compound involving amines and cardanol.  The noteworthy feature of the work is the utilization of an eco-friendly compound from renewable source as the starting material.

Principle Investigator: Dr. T. Ramachandran
Co-Investigator: Dr. T.G. Satheesh Babu


Our proud sponsors include Department of Biotechnology (DBT) Govt. of India, Indian Space Research Organization  (ISRO), and Defence Research and Development Organization (DRDO), Council of Scientific and Industrial Research  

Department of Biotechnology
Ministry of Science and Technology,
Government of India
Government of India
Department of Science & Technology
Ministry of Science and Technology
Indian Space Research Organization (ISRO)
Council of Scientific and Industrial Research
NIRF 2018