Projects

[DBT] Affordable paper based microfluidics point of care testing device for liver function

Liver function test is one of the commonly performed blood analyses. Colorimetric test for the estimation of liver enzymes and total proteins are well established. The objective of this project is to integrate all the colorimetric tests into a paper based micropad that requires very low sample volume. The fabrication of low-cost microfluidic devices based on paper are increasingly popular as they are inexpensive, simple to use, allow passive transport of fluids without active pumping and can easily take advantage of existing analytical techniques. Here a vertical flow design consisting of a filter capable of separating blood cells from plasma and a wax ink patterned on chromatographic paper with wells for each analyte has been designed. This design has advantages including small sample size, quick response, simple construction and less weight. Solutions of the reagents for the assays will be inkjet printed in the test zones and dried. Upon introduction of the sample, through capillary action the plasma (obtained after filtration) enters each well resulting in biochemical reaction and leads to color formation.

Principle Investigator: Dr. T. G. Satheesh Babu
Co-Investigator:: Dr. Bipin Nair , Dr. T. Ramachandran

[DBT] Cost effective device and cloud enabled smart solution for diabetes care

The joint effort by Amrita and Wipro has the goal of making diabetes care available, accessible and affordable for the Indian masses. Amrita and Wipro has envisaged a patient-centric solution wherein low cost diabetes care devices (glucose strips, glucometers & insulin pumps) will interact with users through mobile applications using the cloud gateway. Innovative features of the device will make diabetes management easier for Indian patients and physicians. While Amrita Institute has in-house capabilities of making innovative low-cost diabetes-care product prototypes, it understandably does not have expertise in incorporating these devices into an integrated infrastructure where the devices can act as touch points between the patient and the healthcare provider through smart interfaces. With a proven track record in fields like remote patient monitoring and cloud & mobile connectivity, Wipro has the perfect complementary expertise in making cloud gateway and infrastructure, device-to-application data transfer and interactive platforms. Thus the synergy between Amrita and Wipro promises to leverage their individual strengths and provide an integrated diabetes care solution.

Principle Investigator: Dr. Bipin Nair, Dr. T. G. Satheesh Babu

[DBT] Development of lab-on-a-chip for the early detection of cancer in women

A method that is specific and reliable for detecting cancers at early stages and of at an affordable cost which can function as a first-line guidance is of utmost importance. Sensor technology has provided a promising future for the detection of many important diseases through rapid, sensitive and easy applications. Getting high specific and sensitive results by this technology for the detection of biomarkers from blood samples may provide both early and easy detection of cancer without pain with a minimally-invasive technique. Due to the high prevalence of breast, cervical and ovarian cancer in Indian women our aim is to develop a device that can detect cancer at an early stage. A lab-on-a-chip device, which integrates sensors that can detect the above mentioned cancers, will be highly pragmatic due to portability, simplicity of use and affordability. Further this proposed technology can be employed for the mass population screening.

Principle Investigator: Dr. T. G. Satheesh Babu

[DBT] Lab-on-a-chip (LOC) for the Monitoring of Diabetes, Cholesterol and Kidney Function

The proposed work envisages the fabrication of microfluidic lab-on-a-chip (LOC) module for non-enzymatic sensing of glucose, cholesterol and creatinine using a single device. This consists of a disposable LOC and a non disposable electronics module. The use of non-enzymatic sensing module helps to achieve longer shelf life, eliminating the need for stringent storage conditions. This reduces the cost and time of analysis considerably. The point of care diagnostic device provides an effective alternative for the existing expensive and time consuming clinical analysis performed by a trained clinical lab technician. This would thereby enable access to low-cost medical diagnostics even to underprivileged sections of the society.

Principle Investigator: Dr. Bipin Nair
Co-Investigator: Dr. T. G. Satheesh Babu, Dr. T. Ramachandran, Mr. K. Guruvayurappan

[ISRO Bangalore] Electrodeposition of Aluminium-Lithium alloys for cryo and space applications

The objective of the work was to develop aluminum alloys containing lithium, copper, and zirconium for aerospace applications. Moderately thick deposits of binary and ternary alloys of aluminum with lithium, copper and zirconium were successfully electrodeposited. This was achieved at room temperature through the use of low cost ionic liquid containing AlCl3 and triethylammine hydrochloride (Et3NHCl). Electroforming was performed on plastic substrates for real-time applications and found to be highly corrosion resistant, a feature extremely important in aerospace and marine applications. The deposited alloys were thoroughly analyzed for its morphology and crystallinity and was observed to be highly uniform and crystalline.

Principle Investigator: Dr. T. G. Satheesh Babu
Co-Investigator: Dr. T. Ramachandran, Dr. M. Sivadayanidhi

[DST-TIFAC CORE] Development of amperometric glucose biosensors (as a part of DST-TIFAC CORE in Biomedical technology)

The aim of the project is develop a glucose sensor which work in closed-loop with the insulin pump.

Synthesis of Lube/fuel additive from CNSL - UTeC Corporation, Colorado, USA

Oil soluble alkyl substituted hydroxy aromatic compounds functionalized with amine or substituted amines are commonly used as additives in lube oil and fuel oil, since these compounds have potential activity as oxidation inhibitor (antioxidant), emulsifier and crank case detergent. Mannich base derivatives of polyisobutenylsucinicanhydride are the most common. Cardanol which is obtained by the distillation (decarboxylation) of cashew nut shell liquid is chemically an alkyl substituted phenol. It is used in all industries from polymer to medicine. The greatest advantage with cardanol is its availability from renewable source, biodegradability and eco-friendly nature. The objective of the project was to synthesize long chain compounds involving amines and cardanols by utilizating eco-friendly compound from renewable source as the starting material.

Principle Investigator: Dr. T. Ramachandran
Co-Investigator: Dr. T.G. Satheesh Babu

Sponsors

Our proud sponsors are: 


Department of Biotechnology
Ministry of Science and Technology,
Government of India


Government of India
Department of Science & Technology
Ministry of Science and Technology


Indian Space Research Organization (ISRO)


Defence Research and Development Organization (DRDO)
 


Council of Scientific and Industrial Research