Qualification: 
MSc, BSc
amritasalim@am.amrita.edu
Phone: 
+91 812927613

Amrita Salim currently serves as a Junior Research Fellow at Amrita School of Biotechnology. She received her M.Sc in Microbiology from Amrita Vishwa Vidyapeetham in 2015.

ALMA MATER

  • M.Sc Microbiology, Amrita Vishwa Vidyapeetham (2015)
  • B.Sc Microbiology, Presentation College of Applied Sciences, Mahatma Gandhi University (2010)
     

AWARDS /HONORS

  • Awarded with junior research fellowship from Amrita Vishwa Vidyapeetham.
  • Selected for IC-IMPACTS summer institute on Nanotechnology at University Of Alberta, Canada.
     

RESEARCH EXPERIENCE

  • The project entitled Isolation and characterization of alkaline protease from Bacillus subtilis in soil at Unibiosys biotech research lab, Ernakulam.
  • The project entitled Isolation and characterization of bacteriophages against enteric pathogens under the guidance of Dr.Sanjay Pal, Assistant Professor, Amrita School Of Biotechnology.
     

ONGOING RESEARCH PROJECT

Bacteriophages to Target and kill Enteric Pathogens and Odor Producing Bacteria in Sewage Water / Funded by DBT - BIRAC - BMGF (Govt. of India - Bill & Melinda Gates Foundation). 

Publications

Publication Type: Patent

Year of Publication Publication Type Title

2018

Patent

S. Pal, Dr. Bipin G. Nair, Madhavan, A., Pradeesh Babu, Amrita Salim, P., C., Stanely, J., and Babu, S., “Methods and devices for detecting antimicrobial resistant bacteria using bacteriophages”, U.S. Patent 2017410206692018.

Publication Type: Conference Paper

Year of Publication Publication Type Title

2018

Conference Paper

Pradeesh Babu, S. J. Poornendu, Amrita Salim, Madhavan, A., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Resazurin based redox dye as an indicator for monitoring wastewater biological activity”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017), Punjab, India, 2018.

Publication Type: Journal Article

Year of Publication Publication Type Title

2018

Journal Article

Chandni P, Amrita Salim, Archana P. V., Pradeesh Babu, Dr. Bipin G. Nair, Madhavan, A., and Dr. Sanjay Pal, “Characterization of the bacteriophages binding to human matrix molecules.”, International Journal of Biological Macromolecules, 2018.[Abstract]


Recent literature has suggested a novel symbiotic relationship between bacteriophage and metazoan host that provides antimicrobial defense protecting mucosal surface by binding to host matrix mucin glycoproteins. Here, we isolated and studied different bacteriophages that specifically interact with human extracellular matrix molecules such as fibronectin, gelatin, heparin and demonstrated their potency for protection to host against microbial infections. We showed that subpopulations of bacteriophages that work against clinical isolates of Escherichia coli can bind to pure gelatin, fibronectin and heparin and reduced bacterial load in human colon cell line HT29. The bacteriophages were characterized with respect to their genome sizes, melting curve patterns and host tropism (cross-reactivity with different hosts). Since, the bacteriophages are non-toxic to the host and can effectively reduce bacterial load in HT29 cell line their therapeutic potency against bacterial infection could be explored.

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