Back close

Novel Anti-MRSA Compounds from Padina tetrastromatica: Identification, Isolation and Mass Spectrometric characterization

School: School of Biotechnology

Project Incharge:Dr. Sudarslal S.
Co-Project Incharge:Abhishek Nair A. Akshay Iyer Akshaya Balasubramanian Prasanth Pillai P. R Shankar Ganesh Vijesh V
Novel Anti-MRSA Compounds from Padina tetrastromatica: Identification, Isolation and Mass Spectrometric characterization

Staphylococcus aureus is a gram-positive pathogen responsible for causing several infectious diseases and has been shown to be one of the leading causes of skin and soft tissue infections and bloodstream infections. The problem is further exacerbated by the development of antibiotic resistance. This necessitates the discovery of novel molecules showing anti-microbial activity against Methicillin-resistant Staphylococcus aureus (MRSA). The marine environment is taxonomically diverse with several possible sources of natural compounds. It also happens to be a relatively untapped and unexplored environment when compared to its terrestrial counterpart. Antimicrobial activities of marine algal extracts against several microorganisms have been reported. Yet the characterization and further investigation of responsible active principles has not been as widely explored. Based on these facts, we have decided to explore the possibility of discovering anti-MRSA compounds of marine algal extracts of as yet unexplored species and characterize the active principle responsible for the inhibitory activity using analytical techniques such as HPLC, TLC and mass spectrometry. In due course, we have observed an array of phenolic compounds, identified as phlorotannins, showed significant anti-MRSA properties, the structures of which are extensively characterized by different mass spectrometric techniques.

Related Projects

Computational Modelling and Prediction of Cerebellar Input Layer function, Timing and Plasticity for Understanding Neurophysiological Disorders
Computational Modelling and Prediction of Cerebellar Input Layer function, Timing and Plasticity for Understanding Neurophysiological Disorders
Antimicrobial Activity of Selected Plant Extracts on Multi Drug Resistant Staphylococcus Aureus
Antimicrobial Activity of Selected Plant Extracts on Multi Drug Resistant Staphylococcus Aureus
Quorum Sensing and Biofilm Formation in Microbial Pathogenesis
Quorum Sensing and Biofilm Formation in Microbial Pathogenesis
The Discovery of MicroRNAs (miRNAs) that Regulate the Expression of Gelatinase A (Matrix metalloproteinase-2/MMP-2) and B (Matrix metalloproteinase-9/MMP-9) in Colon Cancer Cells
The Discovery of MicroRNAs (miRNAs) that Regulate the Expression of Gelatinase A (Matrix metalloproteinase-2/MMP-2) and B (Matrix metalloproteinase-9/MMP-9) in Colon Cancer Cells
Amrita Insulin Pump and Low-cost, Automated Biomedical Devices
Amrita Insulin Pump and Low-cost, Automated Biomedical Devices
Admissions Apply Now