Qualification: 
Ph.D, MSc
akhilsivan@am.amrita.edu

Dr. Akhil Sivan currently serves as Assistant Professor at the Department of Chemistry, Amrita School of Arts and Sciences, Amritapuri. He completed his Bachelor’s degree in Industrial Chemistry from T. K. M. M. College, Nangiarkulangara with University level 3rd rank (University of Kerala) in 2005 and Master's degree in Advanced Organic Chemistry from S. D. College, Alappuzha (University of Kerala) in 2008. He completed his Ph. D. from Amrita Vishwa Vidyapeetham in 2018 in the broad subject area of “Synthetic Organic Chemistry”, where special emphasis has been given for the synthesis of heterocycles and spirocycles and for the construction of carbon-carbon and carbon-heteroatom bonds using Cerium(IV) Ammonium Nitrate (CAN) as a single electron transfer oxidant.

Research Experience

  • Junior Project Fellow, Dept. of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri
    • Project Title: “Macrocyclic and carbocyclic constructions mediated by SET oxidations of styrenes, allenes and cyclopropanes”, sponsored by Department of Science and Technology (DST), Govt. of India, New Delhi. 
    • Highlights:
      • Synthesis of macrocyclic crown ethers containing fluorene molecules by single electron oxidation.
      • Study of the effect of the length of the styrene tether on the properties of the macrocyclic crown ether.
      • Synthesis of benzannulated heterocycles by the intramolecular cyclization of suitable precursors.
      • Study of the single electron oxidation behavior of acetylenes and allenes and additions of these to 1,3-dicarbonyl systems.
      • Synthesis of vicinal tricarbonyl compounds by the single electron oxidation of 1,3-dicarbonyl systems.
      • Comparative study of the single electron oxidation potential of Fe (III) and Ag (I) salts. 
         
  • Research Assistant, VALUE Virtual Labs, Amrita Vishwa Vidyapeetham, Amritapuri
    • Project Title: MHRD sponsored project under National Mission on Education through ICT. 
       
  • Research Scholar, Dept. of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri
    • Thesis Title: "New Synthetic Methods for Multi-Substituted Furans, Vicinal Triketones and Benzylidene Fluorene Derivatives Using Cerium(IV) Ammonium Nitrate"
    • Highlights:
      • Developed a new method for the preparation of tetrasubstituted and fused furans by the oxidative addition of terminal acetylenes to 1,3-dicarbonyl compounds in the presence of CAN.
      • A mild protocol for the synthesis of VTCs from β-dicarbonyl compounds has been achieved by using catalytic amounts of CAN.
      • A mild and improved method for the synthesis of spirodihydrofuran fluorenes and dinitrato adducts of benzylidene and diphenyl methylidenefluorene has been discovered using solid phase CAN reaction.
      • Carried out the dinitration of benzylidene and diphenyl methylidenefluorene using CAN supported on silica.

Professional Experience

  • Assistant Professor on Contract, Dept. of Chemistry, T. K. M. M. College, Nangiarkulangara.
  • Assistant Professor on Contract, Dept. of Chemistry, St. Michael’s College, Cherthala.
  • Teaching Assistant, Dept. of Chemistry, Amrita Vishwa Vidyapeetham, Kollam, Kerala.

Publications

Publication Type: Journal Article

Year of Publication Title

2020

S. John, Kavya, G., Aparna, M. M., R Krishnan, A., Parvathy, R., Sreenath, T. S., and Akhil Sivan, “Organic base catalysed synthesis of benzimidazole”, IOP Conference Series: Materials Science and Engineering, vol. 872, p. 012142, 2020.[Abstract]


A mild and effective protocol for benzimidazolesynthesis from o-phenylenediamine and aromatic aldehydes catalysed by DBU is described. The synthesized compounds find application in the pharmaceutical, dye and material science fields. Mild reaction conditions, low amount of chemicals and use of metal-free catalysts are the highlights of the reaction.

More »»

2019

M. Leema, Sreekumar, G., Akhil Sivan, and Dr. Zeena S. Pillai, “Synthesis of silver nanoparticles from a bioactive precursor”, Materials Today: Proceedings, vol. 18, pp. 4724-4728, 2019.[Abstract]


Silver nanoparticles are well known for their medicinal properties from time immemorial. Improving their potential applications demands a greener approach to synthesise them. Embelin, a bioactive molecule belonging to the Myrsinaceae family has gained considerable research interest over the past few years due to its diverse properties as anti-inflammatory, antitumour, analgesic and antimicrobial agent. Being an antioxidant, embelin is capable of reducing metal to metal nanoparticles. In this report, reduction of silver to silver nanoparticles has been carried out using embelin. The silver nanoparticles thus formed were characterised using absorption spectroscopy as well as TEM measurement. The synergic effect on the activity of the silver-embelin system is compared with pure embelin

More »»

2014

Akhil Sivan and A. Deepthi, “Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate”, Tetrahedron Letters, vol. 55, pp. 1890-1893, 2014.[Abstract]


A mild and efficient protocol for the synthesis of vicinal tricarbonyl compounds from β-dicarbonyls in a single step using cerium(IV) ammonium nitrate as a catalytic oxidant is described. Ease of execution, wide substrate scope and the suitability for the synthesis of commercially important compounds like ninhydrin, alloxan and oxoline make this reaction particularly noteworthy. More »»

2011

Akhil Sivan, A. Deepthi, and V. Nandialath, “Oxidative addition of 1,3-dicarbonyl compounds to terminal acetylenes mediated by cerium(IV) ammonium nitrate”, Synthesis, vol. 15, pp. 2466-2470, 2011.[Abstract]


Cerium(IV) ammonium nitrate mediated oxidative addition of 1,3-dicarbonyl compounds to terminal acetylenes to yield multisubstituted furan derivatives is reported here. The simplicity of the reaction and the ease of execution are particularly noteworthy.

More »»

Publication Type: Conference Proceedings

Year of Publication Title

2014

Akhil Sivan and A. Deepthi, “A Direct Synthesis of Vicinal Triketones from β-Diketones: 1,3 to 1,2,3”, 16th CRSI National Symposium in Chemistry. IIT Bombay, Powai, Mumbai, 2014.

2014

R. Anchu, Akhil Sivan, and A. Deepthi, “1,3-Diones to 1,2,3-Triones and 1,3,5-Triones to 1,2,3,4,5-Pentones”, National Symposium on Transcending Frontiers in Organic Chemistry. NIIST, Trivandrum, Kerala, 2014.

2014

Akhil Sivan, A. Deepthi, and K. S. Nair, “An Efficient Synthesis of Spiro Dihydrofuran Fluorenes Using CAN Supported on Silica”, National Seminar on Frontiers of Polymers and Advanced Materials. Dept. of Chemistry, University of Kerala, Trivandrum, Kerala, 2014.

2012

Akhil Sivan and A. Deepthi, “Reactivity of Ethyl-2,3-butadienoate in Cerium (IV) ammonium nitrate (CAN) mediated intermolecular C-C bond formation”, 14th CRSI National Symposium in Chemistry. NIIST, Trivandrum, Kerala, 2012.

2011

Akhil Sivan and A. Deepthi, “Synthesis of tetrasubstituted furans by oxidative addition”, Recent Trends in Organic Synthesis. School of Chemistry, Bharathidasan University, Trichy, Tamil Nadu, 2011.

2011

Akhil Sivan, A. Deepthi, and Vidya, N., “Synthesis of Fused Furans by Oxidative Addition”, National Seminar on Current Trends in Chemistry, Dept. of Applied Chemistry. Cochin University of Science and Technology, Kerala, 2011.

Research Activities

  • Current research group comprises of 7 Post Graduate and 3 Under Graduate students.
  • Successfully completed 2 M. Sc. projects.
  • Co-guided 4 M. Phil. students and 8 M. Sc. students towards the successful completion of their projects during PhD.

Academic Achievements & Awards

  • 3rd rank holder in B. Sc. Industrial Chemistry, University of Kerala.
  • Received “Certificate of Appreciation” from Amrita Vishwa Vidyapeetham University in 2014 for getting international research publication.
  • Received “Certificate of Appreciation” from Amrita Vishwa Vidyapeetham University in 2012 for getting international research publication.