Qualification: 
MSc, BSc
divyanedungadi@am.amrita.edu

Ms Divya Nedungadi P after completing her M.Sc in Biotechnology from Amrita School of Biotechnology in 2012 joined us as a PhD Scholar in the Cancer Biology Lab. She is currently working in a Department of Science and Technology (DST) funded project titled “Paraptosis- A newer approach to target cancer” under Dr Nandita Mishra, Assistant Professor.

ALMA MATER

  • MSc. Biotechnology, Amrita Vishwa Vidyapeetham (2012)
  • BSc. Biotechnology, PSG College of Arts & Science, Coimbatore (2010)

AWARDS / HONOR

  • Award of Excellence from Amrita Vishwa Vidyapeetham,2013
  • Qualified ICMR-Junior Research Fellowship, 2012
  • Qualified GATE exam, 2012

Research experience

  • “Role of calpain and caspase-3 in regulating the mitochondrial fusion protein,Opa-1 during apoptosis”, Rajiv Gandhi Centre for Biotechnology, Kerala under Dr TR Santhoshkumar (Jan 2012-May 2012).
  • Protein purification at MIMS Research Foundation, Kerala under Dr R.V. Thampan (June 2011).
  • Recombinant DNA Technology and PCR, Shreedhar Bhatt Laboratory, Bangalore (May 2009)
     

Publications

Publication Type: Journal Article

Year of Conference Publication Type Title

2017

Journal Article

N. Velusamy, Binoy, A., Bobba, K. Naidu, Nedungadi, D., Dr. Nandita Mishra, and Bhuniya, S., “A bioorthogonal fluorescent probe for mitochondrial hydrogen sulfide: new strategy for cancer cell labeling”, Chem Commun (Camb)., vol. 53, no. 62, pp. 8802-8805, 2017.[Abstract]


We report the application of a chemodosimeter {'}turn on{'} fluorescent probe for detecting endogenous H2S formation in cancer cells. Mito-HS showed a bathochromic shift in the UV-vis-absorption spectrum from 355 nm to 395 nm in the presence of H2S. Furthermore{,} it showed an [similar]43-fold fluorescence enhancement at [small lambda]em = 450 nm in the presence of H2S (200 [small mu ]M). The cancer cell-specific fluorescence imaging reveals that Mito-HS has the ability to distinguish cancer cells from normal cells based on the level of endogenous H2S formation. In due course{,} Mito-HS would be a powerful cancer biomarker based on its ability to estimate endogenous H2S formation in living cells.

More »»

2016

Journal Article

Y. K. Yasoda, Bobba, K. Naidu, Nedungadi, D., Dutta, D., M. Kumar, S., Kothurkar, N., Mishra, N., and Bhuniya, S., “GSH-responsive biotinylated poly(vinyl alcohol)-grafted GO as a nanocarrier for targeted delivery of camptothecin”, RSC Adv., vol. 6, pp. 62385-62389, 2016.[Abstract]


A water-soluble and biocompatible polymer{,} i.e. biotinylated poly(vinyl alcohol)-grafted graphene oxide (GO){,} was used as a nanocarrier for targeted delivery of anticancer drug camptothecin (CPT). The extent of CPT release in the presence of glutathione (GSH) from GO-biotinPVA-CPT was monitored by the increase in the fluorescence intensity{,} at [small lambda]max = 450 nm. The cell-specific (HeLa) antiproliferative activity of GO-biotinPVA-CPT makes it suitable to be used for targeted delivery of chemotherapeutics to cancerous cells. More »»

Publication Type: Conference Proceedings

Year of Conference Publication Type Title

2013

Conference Proceedings

N. Mishra, Dr. Sanjay Pal, Nair, R. R., Krishna, A., Ajith, A., V, A., KS, D., Nedungadi, D., and P, C., “Expression and refolding of recombinant staphylococcal amidases in E. coli”, Proceedings of International Conference on Biotechnology for Innovative Applications (Amrita BioQuest 2013). Elsevier Publications, p. 106, 2013.

Faculty Research Interest: 
207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
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A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
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